Phase
Condition
N/ATreatment
TCR-T cells
Clinical Study ID
Ages 18-75 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
patients with advanced lung tumor or other solid tumor where biopsy is obtainable
Life expectancy >12 weeks
Child-Pugh-Turcotte score <7
Adequate heart,lung,liver,kidney function
Available autologous transduced T cells with greater than or equal to 20% expressionof targeted TCR sequences determined by flow-cytometry and killing of tumor cellsgreater than or equal to 20% in cytotoxicity assay
Informed consent explained to, understood by and signed by patient/ guardian.Patient/guardian given copy of informed consent. -
Exclusion
Exclusion Criteria:
Had accepted gene therapy before;
Tumor size more than 25cm;
Severe virus infection such as HBV, HCV, HIV, et al
Known HIV positivity
History of lung transplantation
Active infectious disease related to bacteria, virus,fungi,et al
Other severe diseases that the investigators consider not appropriate;
Pregnant or lactating women
Systemic steroid treatment (greater than or equal to 0.5 mg prednisoneequivalent/kg/day)
Other conditions that the investigators consider not appropriate.
Study Design
Study Description
Connect with a study center
The Second Affiliated Hospital of Guangzhou Medical University
Guanzhou, Guangdong 51260
ChinaActive - Recruiting
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