Evaluating Structural and Functional Changes of Brain by fMRI and DTI in Patients With Intracranial Germ Cell Tumors

Last updated: July 25, 2019
Sponsor: Beijing Neurosurgical Institute
Overall Status: Active - Recruiting

Phase

N/A

Condition

Germ Cell Tumors

Testicular Cancer

Treatment

N/A

Clinical Study ID

NCT03771625
2018-GEMF-1073
  • Ages > 3
  • All Genders

Study Summary

BOLD-fMRI and DTI scans are performed to patients with germ cell tumors in the basal ganglia before and after treatments. The changes of the MRI and muscle strength of patients during treatments are evaluated, and the association between these two are investigated.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. age ≥3 years;

  2. no history of brain radiotherapy;

  3. no other known cause of movement and cognitive impairment;

  4. no contraindications to the magnetic resonance imaging (MRI) scan;

Exclusion

Exclusion Criteria:

  1. patients can not tolerate MR scan;

  2. head motion is greater than 3 mm during functional MRI scanning.

Study Design

Total Participants: 30
Study Start date:
June 01, 2019
Estimated Completion Date:
November 01, 2021

Study Description

Primary intracranial germ cell tumors are a specific entity of brain tumors with a variety of histological types and different degrees of malignancy. Intracranial GCTs make up 11.2% - 15.3% of primary intracranial tumors in Asian children compared with 3.6% in the US. And tumors located at the basal ganglia is much rarer.

The investigators realize that most of patients with tumors at this location are involved with motor disfunction. And after treatments, some patients get relieved dramatically, but some others failed to get similar outcomes. To better understand the mechanism causing this difference of treatment outcomes, the investigators perform BOLD-fMRI and DTI scans to patients with germ cell tumors in the basal ganglia before and after treatments. The changes of the fMRI and muscle strength of patients during treatments are evaluated, and the association between these two are investigated.

Connect with a study center

  • Beijing Tiantan Hospital

    Beijing, 100071
    China

    Active - Recruiting

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