Natural Treatments for the Management of Emotional Dysregulation in Youth With Non-verbal Learning Disability (NVLD) and/or Autism Spectrum Disorders (ASD)

Inclusion Criteria:

• A previous established diagnosis of non-verbal learning disability (NVLD) or DSM-VAutism Spectrum Disorder and/ or combined T-scores on the Child Behavior Checklist > 195 on the Withdrawn + Social Problems + Thought Problems subscales.

• Current symptoms of emotional dysregulation as indicated by combined T-scores on theChild Behavior Checklist > 180 on the Anxiety/Depression + Aggression + Attentionsubscales.

• Subjects and their caregivers must be English-speaking and have a level ofunderstanding sufficient to communicate intelligently with the investigator andstudy coordinator, and to cooperate with all tests and examinations required by theprotocol.

• Subjects and their caregivers must be willing and able to comply with all studyprocedures.

• Each subject and his/her authorized legal representative must understand the natureof the study. The subject's authorized legal representative must sign an informedconsent document and the subject must sign an informed assent document.

• Subject must be able to swallow pills.

• Subject must have access to a computer with a camera, speaker, microphone, andinternet connection.

Exclusion Criteria:

• Investigator and his/her immediate family; defined as the investigator's spouse,parent, child, grandparent, or grandchild.

• Serious or unstable illness including hepatic, renal, gastroenterological,respiratory, cardiovascular (including ischemic heart disease), endocrinologic,neurologic, immunologic, or hematologic disease.

• History of bleeding diathesis, including those with von Willebrand disease.

• Uncorrected hypothyroidism or hyperthyroidism.

• History of sensitivity to omega-3 fatty acids, inositol or NAC. A non-responder orhistory of intolerance to omega-3 fatty acid, inositol or NAC after 2 months oftreatment at adequate doses as determined by the clinician.

• Severe allergies or multiple adverse drug reactions.

• Unstable or untreated seizure disorder.

• DSM-IV substance use, abuse or dependence.

• Judged clinically to be at serious suicidal risk for C-SSRS score ≥ 4.

• Current diagnosis of schizophrenia.

• Current diagnosis or symptoms of psychosis.

• IQ < 70.

• Pregnant or nursing.

• Weighs less than 12.5kg.