Natural Treatments for the Management of Emotional Dysregulation in Youth With Non-verbal Learning Disability (NVLD) and/or Autism Spectrum Disorders (ASD)

Inclusion Criteria:

• A previous established diagnosis of non-verbal learning disability (NVLD) or DSM-VAutism Spectrum Disorder and/ or combined T-scores on the Child Behavior Checklist > 195 on the Withdrawn + Social Problems + Thought Problems subscales.
• Current symptoms of emotional dysregulation as indicated by combined T-scores on theChild Behavior Checklist > 180 on the Anxiety/Depression + Aggression + Attentionsubscales.
• Subjects and their caregivers must be English-speaking and have a level ofunderstanding sufficient to communicate intelligently with the investigator and studycoordinator, and to cooperate with all tests and examinations required by theprotocol.
• Subjects and their caregivers must be willing and able to comply with all studyprocedures.
• Each subject and his/her authorized legal representative must understand the nature ofthe study. The subject's authorized legal representative must sign an informed consentdocument and the subject must sign an informed assent document.
• Subject must be able to swallow pills.
• Subject must have access to a computer with a camera, speaker, microphone, andinternet connection.

Exclusion Criteria:

• Investigator and his/her immediate family; defined as the investigator's spouse,parent, child, grandparent, or grandchild.
• Serious or unstable illness including hepatic, renal, gastroenterological,respiratory, cardiovascular (including ischemic heart disease), endocrinologic,neurologic, immunologic, or hematologic disease.
• History of bleeding diathesis, including those with von Willebrand disease.
• Uncorrected hypothyroidism or hyperthyroidism.
• History of sensitivity to omega-3 fatty acids, inositol or NAC. A non-responder orhistory of intolerance to omega-3 fatty acid, inositol or NAC after 2 months oftreatment at adequate doses as determined by the clinician.
• Severe allergies or multiple adverse drug reactions.
• Unstable or untreated seizure disorder.
• DSM-IV substance use, abuse or dependence.
• Judged clinically to be at serious suicidal risk for C-SSRS score ≥ 4.
• Current diagnosis of schizophrenia.
• Current diagnosis or symptoms of psychosis.
• IQ < 70.
• Pregnant or nursing.
• Weighs less than 12.5kg.