Exome Sequencing Study in Cardiomyopathy to Identify New Risk Variants

Last updated: February 15, 2023
Sponsor: Tongji Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Cardiomyopathy

Circulation Disorders

Treatment

N/A

Clinical Study ID

NCT03754101
TJ-DM-GENE
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Genetic mutations has been proved to be associated wth the onset of cardiomyopathy. In the present study, we intend to identify new related variants or genes. From March, 2003 to November, 2017, patients diagnosed as cardiomyopathy were consecutively recruited, and their sampled were drawn from peripheral blood. Paired control group were also enrolled. The whole exome sequencing was used to find out the variants associated with the onset of cardiomyopathy and its prognosis.

Eligibility Criteria

Inclusion

Inclusion Criteria:

· Patients diagnosed as cardiomyopathy according to the definition of American HeartAssociation

Exclusion

Exclusion Criteria:

  • Uncontrolled hypertension significant valvular disease
  • Mild ischemic heart disease
  • Significant systemic infection
  • Thyroid-induced cardiomyopathy
  • Excessive alcohol consumption
  • Precious cancer treatment including irradiation
  • Refusal to participate in the study

Study Design

Total Participants: 4000
Study Start date:
March 03, 2003
Estimated Completion Date:
October 31, 2025

Connect with a study center

  • Tongji Hospital

    Wuhan, Hubei 430030
    China

    Active - Recruiting

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