Fertility Preservation in Case of Endometriosis

Last updated: March 1, 2019
Sponsor: Assistance Publique - Hôpitaux de Paris
Overall Status: Active - Recruiting







Clinical Study ID

  • Ages 18-36
  • Female

Study Summary

Fertility Preservation is now considered as crucial for the well-being of women battling cancer. However, others indications have more recently emerged. Women with endometriosis may represent a suitable group since they are at risk for compromise ovarian reserve. Data on FP in endometriosis patients are rare: only small retrospective study, case-reports and opinion publications .Nowadays, there is no available data concerning real indications for PF on endometriosis patients (endometriomas, risk of surgery, deep endometriosis?), criteria for eligibility (ovarian reserve parameters, age), quality of oocytes and number of oocytes necessary to give at least one live birth.

We propose a monocentric observational cohort study, evaluating the efficacy of oocytes cryopreservation as fertility preservation procedure, in young adult female subjects with endometriosis, to finally define the criteria of eligibility for PF procedures in case of endometriosis.

Eligibility Criteria


Inclusion Criteria:

  • women from 18 to 36 years old

  • endometriosis disease proved by sonography, MRI and/or surgery

  • Consenting to participate to the study


Exclusion Criteria:

  • Any contraindication for ovarian stimulation.

  • Any contraindication for pregnancy .- Impossible Follow-up.

Study Design

Total Participants: 100
Study Start date:
December 04, 2018
Estimated Completion Date:
December 31, 2025

Study Description

Monocentric observational cohort study, enrolling young patients with endometriosis, without birth project for the moment, and asking for fertility preservation, in order to preserve mature oocytes.

Protocol of this study :

  • information and signatures of consent file ;

  • ovarian stimulation, oocytes retrieval and mature oocytes cryopreservation (one or more procedures)

  • questionnaires every year, describing quality of life in this context of endometriosis and evolution (treatment, surgery, ART, pregnancies)

  • data about number and rate of thawed oocytes after preservation, pregnancy rate and live birth rate with these oocytes.

Connect with a study center

  • Service de Gynécologie Obstétrique et Médecine de la Reproduction Hôpital TENON

    Paris, Ile De France 75020

    Active - Recruiting

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