Efficacy and Safety of Olaparib (MK-7339) in Participants With Previously Treated, Homologous Recombination Repair Mutation (HRRm) or Homologous Recombination Deficiency (HRD) Positive Advanced Cancer (MK-7339-002 / LYNK-002)

Inclusion Criteria:

• For all participants:

• Has measurable disease per RECIST 1.1 or PCWG-modified RECIST 1.1 as assessed by thelocal site Investigator/radiology and confirmed by BICR.

• Is able to provide a newly obtained core or excisional biopsy of a tumor lesion oreither an archival formalin-fixed paraffin embedded (FFPE) tumor tissue block orslides.

• Has a life expectancy of at least 3 months.

• Has an Eastern Cooperative Oncology Group (ECOG) performance status of either 0 or 1, as assessed within 7 days of treatment initiation.

• Male participants must agree to use contraception during the treatment period andfor at least 95 days (3 months and 5 days) after the last dose of study treatmentand refrain from donating sperm during this period.

• A female participant is eligible to participate if she is not pregnant orbreastfeeding, and at least one of the following conditions applies:

1. Is not a woman of childbearing potential (WOCBP).

2. Is a WOCBP and using a contraceptive method that is highly effective with lowuser dependency, or be abstinent from heterosexual intercourse as theirpreferred and usual lifestyle (abstinent on a long term and persistent basis),during the intervention period and for at least 180 days after the last dose ofstudy intervention, AND agrees not to donate eggs (ova, oocytes) to others orfreeze/store for her own use for the purpose of reproduction during thisperiod. Abstains from breastfeeding during the study intervention period andfor at least 30 days after the last dose of study intervention.

• Has adequate organ function.

• For participants who have non-breast or -ovarian cancers that are breast cancersusceptibility gene 1/2 (BRCA1/2) mutated (BRCAm), or who have cancers that areBRCA1/2 non-mutated and homologous recombination repair nonmutated:

• Has a histologically- or cytologically-confirmed advanced (metastatic and/orunresectable) solid tumor (except ovarian cancer whose tumor has a germline orsomatic BRCA mutation and breast cancer whose tumor has a germline BRCA mutation)that is not eligible for curative treatment and for which standard of care therapyhas failed. Participants must have progressed on or be intolerant to standard ofcare therapies that are known to provide clinical benefit. There is no limit on thenumber of prior treatment regimens.

• Has either centrally-confirmed known or suspected deleterious mutations in at least 1 of the genes involved in HRR or centrally-confirmed HRD.

• For participants receiving prior platinum (cisplatin, carboplatin, or oxaliplatineither as monotherapy or in combination) for advanced (metastatic and/orunresectable) solid tumor, have no evidence of disease progression during theplatinum chemotherapy or ≤4 weeks of completing the platinum-containing regimen.

• For participants who have somatic BRCAm breast cancer:

• Has histologically- or cytologically-confirmed breast cancer with evidence ofmetastatic disease.

• Has a known or suspected deleterious mutation in breast cancer susceptibility gene (BRCA) 1 or BRCA2 and does not harbor a germline BRCA1 or BRCA2 mutation - testingcan be done centrally or locally. Blood and tissue samples must be provided by allparticipants.

• Has received treatment with an anthracycline unless contraindicated and a taxane ineither the neoadjuvant/adjuvant or metastatic setting.

• Participants with estrogen and/or progesterone receptor-positive disease must havereceived and progressed on at least one endocrine therapy (adjuvant or metastatic),or have disease that the treating physician believes to be inappropriate forendocrine therapy.

Exclusion Criteria:

• Has a known additional malignancy that is progressing or has required activetreatment in the last 5 years. Note: Participants with basal cell carcinoma of theskin, squamous cell carcinoma of the skin, ductal carcinoma in situ, or cervicalcarcinoma in situ that has undergone potentially curative therapy are not excluded.

• Has myelodysplastic syndrome (MDS)/acute myeloid leukemia (AML) or with featuressuggestive of MDS/AML.

• Has known central nervous system (CNS) metastases and/or carcinomatous meningitis.Note: Participants with previously treated brain metastases may participate ifradiologically stable, clinically stable, and without requirement for steroidtreatment for at least 14 days prior to the first dose of study treatment.

• Has received colony-stimulating factors (e.g., granulocyte colony-stimulating factor [G-CSF], granulocyte-macrophage colony-stimulating factor [GM-CSF] or recombinanterythropoietin) within 28 days prior to the first dose of study treatment.

• Has a known history of human immunodeficiency virus (HIV) infection.

• Has known active hepatitis infection (i.e., Hepatitis B or C).

• Is unable to swallow orally administered medication or has a gastrointestinaldisorder affecting absorption (e.g., gastrectomy, partial bowel obstruction,malabsorption).

• Has received prior therapy with olaparib or with any other polyadenosine 5'diphosphoribose (poly[ADP ribose]) polymerization (PARP) inhibitor.

• Has a known hypersensitivity to the components or excipients in olaparib.

• Has received previous allogenic bone-marrow transplant or double umbilical cordtransplantation (dUCBT).

• Has received a whole blood transfusion in the last 120 days prior to entry to thestudy. Packed red blood cells and platelet transfusions are acceptable if notperformed within 28 days of the first dose of study treatment.

• Has received any anti-neoplastic systemic chemotherapy or biological therapy,targeted therapy, or an anticancer hormonal therapy within 3 weeks prior to thefirst dose of study intervention.

• Has a primary cancer of unknown origin.

• Has received prior radiotherapy within 2 weeks of start of study intervention.Participants must have recovered from all radiation-related toxicities, not requirecorticosteroids, and not have had radiation pneumonitis. A 1-week washout ispermitted for palliative radiation (≤2 weeks of radiotherapy) to non-CNS disease.