Effect of Topical Sulforaphane on Skin Aging and With Ultraviolet and Visible Light Exposure

Inclusion Criteria:

• Participants must be over the age of 18 years old with healthy skin or moderatedegree of photoaging/intrinsic aging;

• Must be healthy enough to undergo skin biopsy, light irradiation, and other studyprocedures in the opinion of the investigator;

• Must be willing to comply with the requirements of the protocol;

• Must have the ability to understand and communicate with the investigator;

• Participant must provide informed consent.

Exclusion Criteria:

• Subjects who are unable to provide informed consent;

• Subject with significant medical history or current skin diseases that theinvestigator feels is not safe for study participation;

• Subjects who have been treated with systemic retinoids or steroids within the pastmonth prior to entry to the study;

• Subjects who have been treated with topical steroids, retinoids or other topicaldrugs used within 2 weeks prior to entry to the study;

• Recently treated or current skin diseases that would affect clinical evaluation andbiopsy;

• Subjects with a known allergy to broccoli.

• Presence or suspicion of bleeding disorder or diathesis which would complicatebiopsy.

• Subjects with a history of excessive scar or keloid formation in the past 10 years.

• Pregnant or nursing subjects (self-reported).

• Subjects with known allergy to anesthetics used.

• Patients with history of investigational drug use in the 30 days prior to entry intothe study.