Anesthetic Efficacy of 2% Mepivacaine Versus 4% Articaine

Last updated: October 31, 2018
Sponsor: Cairo University
Overall Status: Active - Recruiting

Phase

2/3

Condition

Acute And Chronic Dental Pain

Treatment

N/A

Clinical Study ID

NCT03725579
CEBD-CU-2014-06-01
  • Ages 20-50
  • All Genders

Study Summary

The aim of this prospective randomized clinical trial was compare between 2% Mepivacaine and 4% Articaine for inferior alveolar nerve blocks in patients with symptomatic irreversible pulpitis in mandibular molars as regards to their anesthetic efficiency; during access cavity preparation and instrumentation.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Patients in good health (American Society of Anesthesiologists Class II or higher)

  2. Patients having symptomatic irreversible pulpitis in one of their mandibular molars.

  3. Age range is between 20 and 50 years.

  4. Patients who can understand Visual Analogue Scales VAS.

  5. Patients able to sign informed consent

Exclusion

Exclusion Criteria:

  1. Patients allergic to articaine and/or mepivacaine and/or sulfur

  2. Patients having active sites of pathosis in the area of injection.

  3. Patients having active pain in more than one molar.

  4. Patients who had taken analgesics in the 12 hours preceding the injection.

Study Design

Total Participants: 66
Study Start date:
September 15, 2018
Estimated Completion Date:
December 31, 2018

Study Description

Sixty-six patients diagnosed clinically and radiographically with symptomatic irreversible pulpitis in mandibular posterior teeth will received single-visit root canal treatment using ProTaper Universal rotary system for canal preparation, then they will be randomly divided into two groups (n=33) according to the anesthetic solution used, either Group M (3.6 ml Mepivacaine hydrochloride 2% with 1:100000 epinephrine) or Group A (3.4 ml Articaine hydrochloride 4% with 1:100000 epinephrine). The pain will be assessed using numerical rating scale (NRS) during access cavity preparation and instrumentation, then the need for supplemental anesthesia will be also recorded.

Connect with a study center

  • Faculty of Dentistry

    Cairo,
    Egypt

    Active - Recruiting

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