Study to Assess Safety, Tolerability and Efficacy of Afabicin in The Treatment of Participants With Bone or Joint Infection Due to Staphylococcus

Key Inclusion Criteria:

• Able to provide written informed consent and to comply with study procedures.

• Diagnosis of bone or joint infection which fulfils the following conditions: a)Infection is due to S. aureus (MSSA or MRSA) and/or CoNS only; and, b) Participantshad received no more than 7 days of empiric antibiotics prior to initiatingtreatment with study drug unless the pathogen isolated was resistant to theadministered empiric antibiotics; and, c) Biofilm is not considered to be yetestablished and/or has been mechanically eradicated; and, d) Infection is notassociated with an ischiatic or a sacral osteomyelitis; and e) Infection can involveperiosteal or soft tissue.

Key Exclusion Criteria:

• Presence of co-infection with non-staphylococcal bacteria at the affected joint orbone site, or in the blood.

• Participants at an increased risk of developing liver injury.

• Participants who have medical conditions that increase the risk of QT prolongation.

• Medical history within the previous 3 months of: myocardial infarction, unstableangina pectoris, coronary artery or cerebral revascularization procedure or stroke,ventricular tachycardia, multifocal ventricular ectopics requiring treatment, or anyother clinically relevant symptomatic ventricular arrhythmias.

• Documented history of alcohol or drug abuse within the previous 12 months.

• For patients with DFO:

1. Severe peripheral arterial disease (PAD) requiring revascularization; however,patients with peripheral artery disease are eligible for inclusion, providedthey have undergone successful revascularization or it has been deemedunnecessary by a vascular surgeon

2. Necrotizing fasciitis or gangrene requiring complete lower extremity amputation (of all infected bone and soft tissue).

3. Patients with Charcot foot (suspected neuro-osteoarthropathy according toInvestigator's judgment).

4. Need for digital amputation.

• Life expectancy of less than 1 year.