Osteochondral Allograft in the Surgical Treatment of Basal Joint Arthritis

Last updated: April 3, 2025
Sponsor: Columbia University
Overall Status: Suspended

Phase

N/A

Condition

Joint Injuries

Treatment

Osteochondral Allograft

Ligament Reconstruction Tendon Interposition

Clinical Study ID

NCT03722537
AAAS2615
  • Ages > 18
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

This is a study comparing the current standard of care surgical treatment to a newer surgical procedure involving the implantation of osteochondral allograft at the base of the thumb. Patients will be followed at 1, 3, 6 months and 1 year post-operatively.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • 18 years of age or older

  • Indicated for operative management of basal joint arthritis

Exclusion

Exclusion Criteria:

  • Pregnant women/fetuses/neonates, prisoners

  • Previously operated on for treatment of basal joint arthritis

Study Design

Total Participants: 200
Treatment Group(s): 2
Primary Treatment: Osteochondral Allograft
Phase:
Study Start date:
November 14, 2019
Estimated Completion Date:
March 31, 2026

Study Description

Basal joint arthritis of the thumb is a common condition associated with considerable morbidity. Many non-operative and operative treatments have been described, but few multicenter prospective evidence based trials exist comparing standard treatments. This continuing search for consensus and improvement of best clinical practice has been reviewed in a thorough meta-analysis of operative treatments for basal joint arthritis. Operative treatments range from osteotomy, partial or complete trapeziectomy with or without reconstruction of the ligaments, tendon interposition to arthrodesis, however the functional outcome varies. Allograft has been previously described in joint replacement / prosthetic implantation surgery in other areas of the body, however not in the thumb. The purpose of this study is to investigate using osteochondral allograft in the surgical intervention phase of treatment for patients with basal joint arthritis.

Connect with a study center

  • Columbia University Irving Medical Center

    New York, New York 10032
    United States

    Site Not Available

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