Herbal Treatment to Improve Chemotherapy Delivery

Inclusion Criteria:

• Patient with pathological diagnosis of colon cancer; no residual tumor at theresection margin.
• tumor-node-metastasis(TNM)Stage II (high-risk)or III colon cancer according to 8thedition of American Joint Committee on Cancer(AJCC)Staging Manual. High-risk stage IIdisease is characterized by at least one of the following:

1. T4 tumor,
2. inadequately sampled nodes (<12 lymph nodes),
3. clinical presentation with bowel obstruction or perforation,
4. poorly differentiated histology ,exclusive of those cancers that are High degreeof microsatellite instability(MSI-H),
5. lymphovascular invasion,perineural invasion(PNI).

• Underwent radical surgery no more than six weeks ago and plan to start chemotherapy.
• Have not been enrolled in other therapeutic clinical trials within the near 30 days.
• Age between 18 to 75 years; All genders; Eastern Cooperative Oncology Group -performance status(ECOG-PS)from 0 to 2; Women who are pregnant, lactating or ofreproductive age are not eligible, while those of reproductive age using securecontraceptives are eligible.
• No history of previous malignancy other than adequately treated in situ carcinoma ofthe uterine cervix or basal or squamous cell carcinoma of the skin, unless there hasbeen a disease-free interval of at least 5 years.
• Laboratory testing: blood routine examination:WBC≥3.5×109/L，NEUT≥1.5×109/L,PLT≥100×109/L,HGB≥90g/L;biochemicaltests:TBIL≤1.5×ULN,AST(SGOT),ALT(SGPT)≤2.5×ULN,Scr≤1.5×ULN;CEA after surgery wasnormal.
• Consented.
• Agree not to be enrolled in other interventional studies during the research.

Exclusion Criteria:

• Patients not suitable for chemotherapy of CapeOX ,which will be determined by theinvestigator or the attending physician.
• Clinically relevant cardiovascular and/or cerebrovascular disease,activehepatitis,severe abnormalities in liver/ renal function tests.
• Known allergy to any of the components of study drug.
• Those who cannot take the study drug orally because of bowel obstruction and/orrequire for peripheral vein nutrition.
• Malabsorption or diseases that affect the absorption.
• Unstable situations or situations that may endanger the safety of patients and theircompliance, such as severe mental illness,schizophrenia.
• Colostomy