Exploratory Evaluation of [11C]-NOP46

Inclusion Criteria:

• All subjects must be 18 years of age or older, able to read, understand, andvoluntarily sign an informed consent document.

For Healthy Volunteers:

• Volunteers must have no current medical history of sustained pain from a focalinjury.

• Negative pregnancy test if female of childbearing potential.

• Women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry andfor the duration of study participation.

Patients with Focal Pain:

• Subjects must have current pain from a focal injury for which they are under aphysician's care.

• Subjects must have moderate to severe pain, defined as >4 on the Visual AnalogueScale

• Subjects must have a negative pregnancy test if female of childbearing potential.

• Women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry andfor the duration of study participation.

Exclusion Criteria:

• Participants with evidence of diffuse pain at the time of enrollment up to agentadministration are to be excluded from this study.

• Inability to discontinue pain medication(s) for 48 hours prior to agentadministration.(Enrolled participants who have taken pain medication within 48 hoursof agent administration may be either withdrawn from the study or rescheduled at thePI's discretion).

• Concomitant medication use (including suspected illicit drugs use) that, in thejudgment of the investigator, would make the participant inappropriate forenrollment.

• Severe concurrent disease, infection, or medical co-morbidity that, in the judgmentof the investigator, would make the participant inappropriate for enrollment.

• Participants who are receiving any other investigational agents.

• Women who are pregnant or breastfeeding.

• Subjects who are unable to tolerate PET/CT imaging.