An Observational Study of Patients With Chronic Hepatitis B (CHB) Infection

Last updated: April 28, 2025
Sponsor: Target PharmaSolutions, Inc.
Overall Status: Active - Recruiting

Phase

N/A

Condition

Hepatitis

Hepatitis B

Liver Disorders

Treatment

All approved therapies for the treatment of Chronic Hepatitis B (CHB)

Clinical Study ID

NCT03692897
TARGET-HBV
  • Ages > 18
  • All Genders

Study Summary

The TARGET-HBV study engages an observational research design to conduct a comprehensive review of outcomes for patients with CHB infection. The initial phase of the study that enrolled patients treated with tenofovir alafenamide (TAF) was successfully completed. The current protocol (Amendment 1) describes the second phase of the study that will engage research activities for patients being managed for CHB in usual clinical practice in the US and Canada. The study addresses important clinical questions regarding the management of CHB by collecting and analyzing data from patients at academic and community medical centers. TARGET-HBV creates a robust database of real-world data regarding the natural history, management, and health outcomes related to antiviral treatments used in clinical practice.

Eligibility Criteria

Inclusion

Inclusion

  1. Male or female patients, age ≥18 years

  2. Being managed for chronic hepatitis B (CHB), including patients who have achieved functional cure and patients with concurrent delta hepatitis

Exclusion

  1. Inability to provide written informed consent

  2. Known history of Human Immunodeficiency Virus (HIV)

  3. History of liver transplantation

Study Design

Total Participants: 5000
Treatment Group(s): 1
Primary Treatment: All approved therapies for the treatment of Chronic Hepatitis B (CHB)
Phase:
Study Start date:
October 11, 2018
Estimated Completion Date:
January 31, 2026

Connect with a study center

  • UHN Toronto General Hospital

    Toronto, Ontario M5G 2C4
    Canada

    Active - Recruiting

  • Banner University Medical Center Phoenix

    Phoenix, Arizona 85006
    United States

    Terminated

  • Asian Pacific Liver Center at Coalition of Inclusive Medicine

    Los Angeles, California 90020
    United States

    Site Not Available

  • California Liver Research Institute

    Pasadena, California 91105
    United States

    Terminated

  • Stanford University

    Redwood City, California 94063
    United States

    Site Not Available

  • UC Davis GI/Hepatology Clinical Trials Unit

    Sacramento, California 95817
    United States

    Terminated

  • Silicon Valley Research Institute

    San Jose, California 95128
    United States

    Terminated

  • Yale University Digestive Diseases

    New Haven, Connecticut 06520
    United States

    Terminated

  • Medstar Georgetown University Hospital

    Washington, District of Columbia 20007
    United States

    Terminated

  • University of Florida

    Gainesville, Florida 32610-0272
    United States

    Terminated

  • University of Miami, Schiff Center for Liver Disease

    Miami, Florida 33136
    United States

    Terminated

  • Atlanta Gastroenterology

    Atlanta, Georgia 30342
    United States

    Terminated

  • Consultative Gastroenterology

    Atlanta, Georgia 30308
    United States

    Terminated

  • Rush Universtiy Medical Center

    Chicago, Illinois 60612
    United States

    Terminated

  • University of Chicago

    Chicago, Illinois 60637
    United States

    Terminated

  • Mercy Medical Center

    Baltimore, Maryland 21202
    United States

    Terminated

  • University of Michigan

    Ann Arbor, Michigan 48109
    United States

    Active - Recruiting

  • Minnesota Gastroenterology, P.A.

    Plymouth, Minnesota 55446
    United States

    Terminated

  • Rutgers, Robert Wood Johnson Medical School

    New Brunswick, New Jersey 08901
    United States

    Terminated

  • Dreamwork Medical, PLLC

    Flushing, New York 11354
    United States

    Terminated

  • Northwell Health Center for Liver Diseases and Transplantation

    Manhasset, New York 11030
    United States

    Terminated

  • Columbia University Medical Center

    New York, New York 10032
    United States

    Terminated

  • NYU Langone Health

    New York, New York 10016
    United States

    Terminated

  • Weill Cornell Medical College

    New York, New York 10021
    United States

    Terminated

  • UNC Liver Center

    Chapel Hill, North Carolina 27599
    United States

    Terminated

  • UT Southwestern Medical Center

    Dallas, Texas 75390
    United States

    Terminated

  • Digestive and Liver Disease Specialist

    Norfolk, Virginia 23502
    United States

    Terminated

  • Bon Secours Liver Institute of Richmond

    Richmond, Virginia 23226
    United States

    Terminated

  • Virginia Commonwealth University

    Richmond, Virginia 23298
    United States

    Terminated

  • Swedish Organ Transplant and Liver Center

    Seattle, Washington 98104
    United States

    Terminated

  • University of Washington/Harborview Medical Center

    Seattle, Washington 98104
    United States

    Terminated

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