An Observational Study of Patients With Chronic Hepatitis B (CHB) Infection

Last updated: September 10, 2025
Sponsor: Target PharmaSolutions, Inc.
Overall Status: Terminated

Phase

N/A

Condition

Hepatitis B

Liver Disorders

Hepatitis

Treatment

All approved therapies for the treatment of Chronic Hepatitis B (CHB)

Clinical Study ID

NCT03692897
TARGET-HBV
  • Ages > 18
  • All Genders

Study Summary

The TARGET-HBV study engages an observational research design to conduct a comprehensive review of outcomes for patients with CHB infection. The initial phase of the study that enrolled patients treated with tenofovir alafenamide (TAF) was successfully completed. The current protocol (Amendment 1) describes the second phase of the study that will engage research activities for patients being managed for CHB in usual clinical practice in the US and Canada. The study addresses important clinical questions regarding the management of CHB by collecting and analyzing data from patients at academic and community medical centers. TARGET-HBV creates a robust database of real-world data regarding the natural history, management, and health outcomes related to antiviral treatments used in clinical practice.

Eligibility Criteria

Inclusion

Inclusion

  1. Male or female patients, age ≥18 years

  2. Being managed for chronic hepatitis B (CHB), including patients who have achieved functional cure and patients with concurrent delta hepatitis

Exclusion

  1. Inability to provide written informed consent

  2. Known history of Human Immunodeficiency Virus (HIV)

  3. History of liver transplantation

Study Design

Total Participants: 1708
Treatment Group(s): 1
Primary Treatment: All approved therapies for the treatment of Chronic Hepatitis B (CHB)
Phase:
Study Start date:
October 11, 2018
Estimated Completion Date:
September 10, 2025

Connect with a study center

  • UHN Toronto General Hospital

    Toronto, Ontario M5G 2C4
    Canada

    Site Not Available

  • UHN Toronto General Hospital

    Toronto 6167865, Ontario 6093943 M5G 2C4
    Canada

    Site Not Available

  • Banner University Medical Center Phoenix

    Phoenix, Arizona 85006
    United States

    Site Not Available

  • Banner University Medical Center Phoenix

    Phoenix 5308655, Arizona 5551752 85006
    United States

    Site Not Available

  • Asian Pacific Liver Center at Coalition of Inclusive Medicine

    Los Angeles, California 90020
    United States

    Site Not Available

  • California Liver Research Institute

    Pasadena, California 91105
    United States

    Site Not Available

  • Stanford University

    Redwood City, California 94063
    United States

    Site Not Available

  • UC Davis GI/Hepatology Clinical Trials Unit

    Sacramento, California 95817
    United States

    Site Not Available

  • Silicon Valley Research Institute

    San Jose, California 95128
    United States

    Site Not Available

  • Asian Pacific Liver Center at Coalition of Inclusive Medicine

    Los Angeles 5368361, California 5332921 90020
    United States

    Site Not Available

  • California Liver Research Institute

    Pasadena 5381396, California 5332921 91105
    United States

    Site Not Available

  • Stanford University

    Redwood City 5386834, California 5332921 94063
    United States

    Site Not Available

  • UC Davis GI/Hepatology Clinical Trials Unit

    Sacramento 5389489, California 5332921 95817
    United States

    Site Not Available

  • Silicon Valley Research Institute

    San Jose 5392171, California 5332921 95128
    United States

    Site Not Available

  • Yale University Digestive Diseases

    New Haven, Connecticut 06520
    United States

    Site Not Available

  • Yale University Digestive Diseases

    New Haven 4839366, Connecticut 4831725 06520
    United States

    Site Not Available

  • Medstar Georgetown University Hospital

    Washington, District of Columbia 20007
    United States

    Site Not Available

  • Medstar Georgetown University Hospital

    Washington D.C. 4140963, District of Columbia 4138106 20007
    United States

    Site Not Available

  • University of Florida

    Gainesville, Florida 32610-0272
    United States

    Site Not Available

  • University of Miami, Schiff Center for Liver Disease

    Miami, Florida 33136
    United States

    Site Not Available

  • University of Florida

    Gainesville 4156404, Florida 4155751 32610-0272
    United States

    Site Not Available

  • University of Miami, Schiff Center for Liver Disease

    Miami 4164138, Florida 4155751 33136
    United States

    Site Not Available

  • Atlanta Gastroenterology

    Atlanta, Georgia 30342
    United States

    Site Not Available

  • Consultative Gastroenterology

    Atlanta, Georgia 30308
    United States

    Terminated

  • Atlanta Gastroenterology

    Atlanta 4180439, Georgia 4197000 30342
    United States

    Site Not Available

  • Consultative Gastroenterology

    Atlanta 4180439, Georgia 4197000 30308
    United States

    Site Not Available

  • Rush Universtiy Medical Center

    Chicago, Illinois 60612
    United States

    Terminated

  • University of Chicago

    Chicago, Illinois 60637
    United States

    Site Not Available

  • Rush Universtiy Medical Center

    Chicago 4887398, Illinois 4896861 60612
    United States

    Site Not Available

  • University of Chicago

    Chicago 4887398, Illinois 4896861 60637
    United States

    Site Not Available

  • Mercy Medical Center

    Baltimore, Maryland 21202
    United States

    Site Not Available

  • Mercy Medical Center

    Baltimore 4347778, Maryland 4361885 21202
    United States

    Site Not Available

  • University of Michigan

    Ann Arbor, Michigan 48109
    United States

    Site Not Available

  • University of Michigan

    Ann Arbor 4984247, Michigan 5001836 48109
    United States

    Site Not Available

  • Minnesota Gastroenterology, P.A.

    Plymouth, Minnesota 55446
    United States

    Site Not Available

  • Minnesota Gastroenterology, P.A.

    Plymouth 5041926, Minnesota 5037779 55446
    United States

    Site Not Available

  • Rutgers, Robert Wood Johnson Medical School

    New Brunswick, New Jersey 08901
    United States

    Site Not Available

  • Rutgers, Robert Wood Johnson Medical School

    New Brunswick 5101717, New Jersey 5101760 08901
    United States

    Site Not Available

  • Dreamwork Medical, PLLC

    Flushing, New York 11354
    United States

    Site Not Available

  • Northwell Health Center for Liver Diseases and Transplantation

    Manhasset, New York 11030
    United States

    Site Not Available

  • Columbia University Medical Center

    New York, New York 10032
    United States

    Terminated

  • NYU Langone Health

    New York, New York 10016
    United States

    Terminated

  • Weill Cornell Medical College

    New York, New York 10021
    United States

    Site Not Available

  • Dreamwork Medical, PLLC

    Flushing 5117472, New York 5128638 11354
    United States

    Site Not Available

  • Northwell Health Center for Liver Diseases and Transplantation

    Manhasset 5125766, New York 5128638 11030
    United States

    Site Not Available

  • Columbia University Medical Center

    New York 5128581, New York 5128638 10032
    United States

    Site Not Available

  • NYU Langone Health

    New York 5128581, New York 5128638 10016
    United States

    Site Not Available

  • Weill Cornell Medical College

    New York 5128581, New York 5128638 10021
    United States

    Site Not Available

  • UNC Liver Center

    Chapel Hill, North Carolina 27599
    United States

    Site Not Available

  • UNC Liver Center

    Chapel Hill 4460162, North Carolina 4482348 27599
    United States

    Site Not Available

  • UT Southwestern Medical Center

    Dallas, Texas 75390
    United States

    Site Not Available

  • UT Southwestern Medical Center

    Dallas 4684888, Texas 4736286 75390
    United States

    Site Not Available

  • Digestive and Liver Disease Specialist

    Norfolk, Virginia 23502
    United States

    Site Not Available

  • Bon Secours Liver Institute of Richmond

    Richmond, Virginia 23226
    United States

    Site Not Available

  • Virginia Commonwealth University

    Richmond, Virginia 23298
    United States

    Terminated

  • Digestive and Liver Disease Specialist

    Norfolk 4776222, Virginia 6254928 23502
    United States

    Site Not Available

  • Bon Secours Liver Institute of Richmond

    Richmond 4781708, Virginia 6254928 23226
    United States

    Site Not Available

  • Virginia Commonwealth University

    Richmond 4781708, Virginia 6254928 23298
    United States

    Site Not Available

  • Swedish Organ Transplant and Liver Center

    Seattle, Washington 98104
    United States

    Site Not Available

  • University of Washington/Harborview Medical Center

    Seattle, Washington 98104
    United States

    Terminated

  • Swedish Organ Transplant and Liver Center

    Seattle 5809844, Washington 5815135 98104
    United States

    Site Not Available

  • University of Washington/Harborview Medical Center

    Seattle 5809844, Washington 5815135 98104
    United States

    Site Not Available

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