The Long Term Effect of Low Dose Aspirin on Uric Acid in Chinese Patients With Coronary Artery Disease（AURORA）

Inclusion Criteria:

1. Patients with coronary artery disease (CAD) who underwent (Percutaneous TransluminalCoronary Intervention) PCI therapy, documenting angiographically at least one vesselstenosis ≥50% among major coronary arteries (left main, left anterior descending, leftcircumflex or right coronary artery) , manifesting clinically as latent CAD, stableCAD, unstable CAD, and acute myocardial infarction.

2. Patients with CAD without PCI therapy. They document angiographically at least onevessel stenosis ≥50% among major coronary arteries (left main, left anteriordescending, left circumflex or right coronary artery) , and classified clinically aslatent CAD, stable CAD, unstable CAD.

3. Patients without CAD who needs antiplatelet therapy for prophylaxis of ASCVD,documenting angiographically no vessel stenosis ≥50% among any of major coronaryarteries (left main, left anterior descending, left circumflex or right coronaryartery).

Exclusion Criteria:

1. Patients with severe conditions with life expectancy less than 12 months.

2. Patients with malignant tumor.

3. Severe Kidney disease: patients with acute kidney injury, nephritic syndrome, renalreplacement therapy, kidney transplant or eGFR <30 mL/min/1.73 m2.

4. Contraindicated to antiplatelet therapy because of acute bleeding.

5. Patients who formerly administrated aspirin for at least one week or withdrawal ofaspirin less than one month before enrollment.

6. Patients who formerly administrated UA lowering agents at least one month beforeenrollment.

7. Patients who formerly administrated, stopped or titrated doses of any of the followingdrugs at least one month before enrollment: losartan, irbesartan, fenofibrate,thiazide and loop diuretics.

8. Patients who administrated ticagrelor as antiplatelet agent one month beforeenrollment or since then.