Predicting Progression of Developing Myeloma in a High-Risk Screened Population (PROMISE)

Inclusion Criteria:

• Age ≥ 30 years

• AA race (self-identified) and/or first-degree relative of a patient with a plasmacell dyscrasia such as MGUS, SMM, MM, and Waldenström's Macroglobulinemia, oranother blood cancer.

• Those over 18 are also eligible if they have 2 or more family members with a bloodcancer

Exclusion Criteria:

• • Persons diagnosed with cancer at any site (including hematologic cancers) with symptomatic disease requiring active therapy.

• Persons with an already diagnosed plasma cell dyscrasia such as MGUS, SMM, MM, and Waldenström's Macroglobulinemia

First-degree relatives would not need to be identified by the participant.

This study includes all special populations who fall within the eligible high-risk age range, ≥ 30 years of age, including adults unable to consent, pregnant women, and prisoners. These populations will not be excluded as this is a non-therapeutic study.