Establish a National Registry of REM Sleep Behavior Disorder

Last updated: August 5, 2021
Sponsor: Chinese University of Hong Kong
Overall Status: Active - Recruiting

Phase

N/A

Condition

Sleep Disorders

Treatment

N/A

Clinical Study ID

NCT03671798
2014.445
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

In this proposed study, the investigators aim to build up a large cohort of Rapid eye movement sleep behavior disorder (RBD) to study the etiology and risk factors of neurodegeneration.

Eligibility Criteria

Inclusion

Inclusion Criteria: Case: According to the ICSD-3 for the diagnosis of RBD

  1. Sleep talking or complex movement during sleep;
  2. Such movement was recorded by video PSG (AV-PSG) during REM sleep or according tohistory the movements were occurred during REM;
  3. REM sleep without atonia (RWA) during PSG monitoring;
  4. This abnormal phenomenon cannot be explained by other sleep disorder, psychiatricdisease, drug or substance abuse. Control: Age and gender matched with consent
  5. No RBD symptoms and PSG characteristics;
  6. No neurological symptoms or diseases, MRI scan will be employed to exclude brainpathology;
  7. No narcolepsy or hypersomnia, ruled out by multiple sleep latency test;
  8. No history of mental illnesses or use of antidepressants.

Exclusion

Exclusion Criteria:

  1. Subjects who refused to join the cohort.

Study Design

Total Participants: 3000
Study Start date:
October 01, 2014
Estimated Completion Date:
April 30, 2022

Study Description

REM sleep behavior disorder (RBD) is a parasomnia characterized by abnormal behavioral manifestations during REM sleep. Accumulating evidence suggests that RBD is implicated as an integral part of disease progress of α-synucleinopathy neurodegeneration, such as Parkinson's disease (PD) and dementia with Lewy bodies.Previous studies have identified a series of neurocognitive, autonomic, clinical and neurobiological markers for neurodegeneration in iRBD, such as olfactory dysfunction, color vision deficit, autonomic dysfunction, tonic EMG activity during REM sleep, and psychiatric disorder. However, the prevalence rate of RBD was relatively low and most of the RBD studies only have 100 or below cases. and there might be ethic differences in RBD which indicates that the findings from western countries might not be applicable to Chinese. In these regards, the investigators aimed to build up a large cohort of Rapid eye movement sleep behavior disorder (RBD) to study the etiology and risk factors of neurodegeneration.

Connect with a study center

  • Department of psychiatry, Faculty of Medicine, The Chinese University of Hong Kong

    Hong Kong,
    Hong Kong

    Active - Recruiting

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