It's Not JUST Idiopathic Pulmonary Fibrosis Study

Last updated: July 1, 2021
Sponsor: University of Nottingham
Overall Status: Active - Recruiting

Phase

N/A

Condition

Pulmonary Fibrosis

Lung Disease

Lung Injury

Treatment

N/A

Clinical Study ID

NCT03670576
18014
  • Ages > 18
  • All Genders

Study Summary

Study of progression of fibrosis in ILD

Eligibility Criteria

Inclusion

Inclusion Criteria

  • Male or female aged ≥ 18 years old
  • Able and willing to give written informed consent
  • Recently diagnosed [defined as diagnostic CT scan or surgical lung biopsy (ifapplicable) >1st May 2017]
  • An MDT diagnosis of fibrotic interstitial lung disease (reticulation, traction +/-honeycombing) Sub Groups
  • Rheumatoid arthritis (rheumatologist diagnosed with anti-CCP antibodies and/orRheumatoid Factor positive)
  • Asbestosis (appropriate occupational history and radiological evidence of asbestosexposure)
  • Chronic HP in accordance with consensus criteria (appropriate exposure history,radiological features +/- avian and fungal precipitins)
  • Unclassifiable fibrotic lung disease (fibrotic lung disease otherwise unclassifiabledespite extensive clinical and radiological examination)
  • IPF in accordance with consensus criteria (ATS/ERS/JRS/ALAT guidelines) as controls

Exclusion

Exclusion Criteria:

  • Participating in an interventional clinic trial
  • Asymptomatic Interstitial Lung Abnormalities (ILA) and normal lung function.
  • Change in clinical phenotype from initial radiological diagnosis to screening
  • Acute Hypersensitivity Pneumonitis.
  • Participants who do not possess a smartphone or have a valid email address (necessaryfor the home FVC readings)

Study Design

Total Participants: 250
Study Start date:
November 11, 2018
Estimated Completion Date:
November 11, 2022

Study Description

The overall aims of this study are

  • Identify biomarkers and gene expression profiles that determine progressive fibrotic lung disease regardless of aetiology

  • To prospectively assess biomarkers which predict progressive fibrosis in patients with fibrosing lung disease of alternate aetiology, including RA-UIP, Asbestosis, Chronic Hypersensitivity Pneumonitis and Unclassifiable fibrotic lung disease

  • Investigate genetic associations and epigenetic modifications which affect fibrotic disease severity and progression

  • Prospectively evaluate longitudinal disease behaviour in patients with non IPF-fibrotic lung diseases with a view to developing composite clinical end-points for subsequent use in intervention studies in patients

Connect with a study center

  • Queens Hospital Burton

    Burton on Trent, Derbyshire DE15 0RB
    United Kingdom

    Active - Recruiting

  • Kings Mill Hospital

    Mansfield, Nottingham NG17 4JL
    United Kingdom

    Site Not Available

  • Royal United Hospitals Bath NHS Trust

    Bath,
    United Kingdom

    Active - Recruiting

  • University Hospitals Birmingham

    Birmingham,
    United Kingdom

    Active - Recruiting

  • Blackpool Victoria Hospital

    Blackpool,
    United Kingdom

    Active - Recruiting

  • Southmead Hospital North Bristol

    Bristol, BS10 5NB
    United Kingdom

    Active - Recruiting

  • University Hospitals Coventry and Warwickshire

    Coventry, CV2 2DX
    United Kingdom

    Site Not Available

  • Royal Derby Hospital

    Derby, DE22 3NE
    United Kingdom

    Active - Recruiting

  • Royal Devon and Exeter Hospital

    Exeter, EX2 5DW
    United Kingdom

    Active - Recruiting

  • Medway Maritime Hospital

    Gillingham, ME7 5NY
    United Kingdom

    Active - Recruiting

  • Kingston Hospital NHS Foundation Trust

    London,
    United Kingdom

    Active - Recruiting

  • St Georges Hospital

    London,
    United Kingdom

    Active - Recruiting

  • North Manchester General Hospital

    Manchester, M8 5RB
    United Kingdom

    Active - Recruiting

  • Wythenshawe Hospital

    Manchester,
    United Kingdom

    Active - Recruiting

  • Newcastle Upon Tyne NHS Foundation Trust

    Newcastle,
    United Kingdom

    Active - Recruiting

  • Northumbria Healthcare NHS Foundation Trust

    Newcastle,
    United Kingdom

    Active - Recruiting

  • Nottingham University Hospitals NHS Trust

    Nottingham, NG5 1PB
    United Kingdom

    Active - Recruiting

  • Sheffield Teaching Hospitals NHS Foundation Trust

    Sheffield,
    United Kingdom

    Active - Recruiting

  • South Tyneside District Hospital

    South Shields, NE34 0PL
    United Kingdom

    Active - Recruiting

  • University Hospital of North Tees

    Stockton-on-Tees, TS19 8PE
    United Kingdom

    Active - Recruiting

  • Taunton and Somerset NHS Foundation Trust

    Taunton,
    United Kingdom

    Active - Recruiting

  • Royal Albert and Edward Infirmary

    Wigan, WN1 2NN
    United Kingdom

    Active - Recruiting

  • New Cross Hospital

    Wolverhampton, WV10 0QP
    United Kingdom

    Active - Recruiting

  • Worcestershire Royal Hospital

    Worcester, WR5 1DD
    United Kingdom

    Active - Recruiting

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