Real World Assessment of Effects of Beta-blockers on Patients With Acute Coronary Syndrome

Last updated: September 13, 2018
Sponsor: Chinese Academy of Medical Sciences, Fuwai Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Heart Disease

Coronary Artery Disease

Cardiac Ischemia

Treatment

N/A

Clinical Study ID

NCT03669991
20181082
  • Ages 18-120
  • All Genders

Study Summary

The study is aimed to optimized the dose-adjusted regimen of beta-blockers in patients with acute coronary syndrome by investigating therapeutic and curative results of target doses Beta-blockers using the dose-adjusted pathway of beta-blockers.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Age ≥ 18 years

  • Patients diagnosed as acute coronary syndromes including acute ST-segment elevationmyocardial infarction (STEMI) and non-ST-segment elevated acute coronary syndrome (NSTE-ACS)

  • Patients or whose legal representatives signed written informed consent form

Exclusion

Exclusion Criteria: Patients should been excluded if they meet any of the following exclusion criteria:

  • Patients with contraindications to the application of beta blockers, including: 1)cardiogenic shock or heart failure (Killip grade > II level);2) sick sinus syndrome;
  1. II degree atrioventricular block;4) unstable decompensation of cardiac failure (pulmonary edema, hypotension or low perfusion); 5) symptomatic hypotension orbradycardia (heart rate<50 beats/min, blood pressure<90/60mmHg); 6) contraindicationsto beta blockers or allergy to any ingredient of beta blocker; 7) active asthma shouldbe treated by inhalation preparation treatment
  • Pregnant or lactating women

  • Patients without signed written informed consent

  • Patients who was considered by the researcher inappropriate to participate in thisstudy (for example, patients with a higher risk of cardiogenic shock, etc.)

Study Design

Total Participants: 2200
Study Start date:
August 31, 2018
Estimated Completion Date:
July 31, 2022

Connect with a study center

  • Fuwai Hospital, Chinese Academy of Medical Sciences

    Beijing, Beijing 100037
    China

    Active - Recruiting

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