Taiwan Cohort - Chronic ThromboEmbolic Pulmonary Hypertension Registry

Last updated: April 23, 2020
Sponsor: National Taiwan University Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Vascular Diseases

Williams Syndrome

Stress

Treatment

N/A

Clinical Study ID

NCT03667391
201709016RIPC
  • Ages > 20
  • All Genders

Study Summary

The diagnosis of chronic thromboembolic pulmonary hypertension (CTEPH) is difficult for numerous reasons and is related with a poor prognosis. In Taiwan, the incidence of CTEPH and its clinical features are unknown. This study aims at evaluating the prevalence, clinical characteristics, and management of CTEPH in a Taiwanese cohort.

Primary objective:

  • To investigate the geodemographics of CTEPH in Taiwan

Secondary objectives:

  • To characterize the demographics and clinical presentation of patients with CTEPH

  • To describe the real-world management and treatment outcome of patients with CTEPH

  • To identify the risk factors of CTEPH

  • To assess the relationship between risk factors/patients' characteristics and clinical outcomes for CTEPH

  • To evaluate the prognosis of CTEPH in Taiwan using survival assessment

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Right heart catheterization (RHC) results that are in line with both of the followinghaemodynamic levels: Mean pulmonary arterial pressure (mPAP) ≥ 25 mmHg at rest AND Pulmonary arterial wedgepressure (PAWP) ≤ 15 mmHg

  2. Confirmation of CTEPH diagnosis by one of the following as recommended by standardguidelines: At least 1 (segmental) perfusion defect(s) in ventilation-perfusion (V/Q) / perfusionscan OR Pulmonary artery obstruction seen by multidetector computed tomography (MDCT)angiography or conventional pulmonary cineangiography.

  3. Presence of pulmonary hypertension or evidence of pulmonary thromboembolism after atleast 3 months of anticoagulation treatment.

Exclusion

Exclusion Criteria:

  • not written informed consent

  • not meet inclusion criteria

Study Design

Total Participants: 200
Study Start date:
January 17, 2018
Estimated Completion Date:
January 01, 2022

Connect with a study center

  • National Taiwan University Hospital

    Taipei, 100
    Taiwan

    Active - Recruiting

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