Laparoscopic Ovarian Drilling Versus Letrozole In Clomiphene Citrate Resistant Polycystic Ovary

Last updated: September 7, 2018
Sponsor: Ain Shams University
Overall Status: Active - Recruiting

Phase

3

Condition

Reproductive Health

Polycystic Ovarian Syndrome

Treatment

N/A

Clinical Study ID

NCT03664050
LOD
  • Ages 20-35
  • Female

Study Summary

The aim of this work is to compare the clinical outcomes of letrozole with laparoscopic ovarian drilling (LOD) in patients with clomiphene-citrate-resistant polycystic ovary syndrome (PCOS).

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. patients diagnosed as PCOS according to Roterdam (2003) criteria

  2. patients with Clomiphene resistance, i.e. failure to ovulate following 100 mg CC for 5days for at least three cycles.

  3. patent fallopian tubes, confirmed by hysterosalpingography or hysteroscopic diagnosis.

  4. normal semen analysis parameters of the patients' spouses according to the modifiedcriteria of the World Health Organization.

  5. normal serum prolactin, thyroid stimulating hormone and 17-OH progesterone.

  6. no systemic disease; no gonadotropin or other hormonal drug treatment during thepreceding 3 months.

Exclusion

Exclusion Criteria:

1- Infertility induced by reasons other than PCOS. 2- uterine cavity lesions or ovariancyst. 3- >40 years old. 4- body mass index (BMI) >26 kg/m2. 5- contraindications to generalanesthesia. 6- history of pelvic surgery. 7- other endocrine diseases. 8- a history ofliver or kidney disease.

Study Design

Total Participants: 90
Study Start date:
January 01, 2018
Estimated Completion Date:
December 01, 2018

Connect with a study center

  • Ain shams university maternity hospital

    Cairo, 25187
    Egypt

    Active - Recruiting

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