Comparison of a Novel Leuprolide With Market Leuprolide

Inclusion Criteria:

1. Males of 18-40 years old (inclusive). The age difference of subjects within andbetween groups should be less than 10 years, at the time of screening.

2. Body weight of at least 50kg. BMI to be 19-24 kg/m2 (inclusive).

3. Able to comprehend the full nature and purpose of the study, including potential risksand side effects; able to cooperate with investigators and to comply with therequirements of the study

4. Signed informed consent form prior to any screening procedures

Exclusion Criteria:

1. Clinically significant and relevant history of cardiovascular, hepatic, renal,hematologic, endocrine, respiratory, neurological diseases or acute/chronic diseasesof the digestive tract.

2. History of hypersensitivity towards leuprolide, synthetic LHRH or LHRH derivatives orany excipients of the study formulation.

3. Abnormal and clinically significant 12-lead ECG

4. Abnormal and clinically significant laboratory assessments

5. Blood donation or blood loss greater than or equal to 400mL within 3 months prior toscreening

6. Participation of clinical trials within 3 months prior to screening

7. Use of any drugs within 2 weeks prior to screening

8. History of drug abuse within 1 year prior to screening

9. History of alcohol abuse within 1 years prior to screening

10. History of tobacco smoking (more than 5 cigarette per day) within 1 year prior toscreening

11. Abnormal testosterone level at screening (not in the range of 168-781ng/dL)

12. Dermatitis or skin anomalies that might affect the administration area and thesurroundings

13. Subject or his partner not willing to adopt appropriate contraceptive measures

14. Subjects have a history of depressive illness or sexual dysfunction;

15. Subjects that the investigator deems unsuitable to be enrolled

16. Subject not willing to cooperate with the investigators.