Radiofrequency Ablation: Treatment for Posterior Element Pain From Vertebral Compression Fractures

Last updated: July 14, 2025
Sponsor: University of California, Davis
Overall Status: Trial Not Available

Phase

4

Condition

Arthritis And Arthritic Pain

Muscle Pain

Treatment

Radiofrequency ablation of the medial branch nerves

Opioids

Non-steroidal anti-inflammatory drugs

Clinical Study ID

NCT03651804
1198963
  • Ages 18-90
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The purpose of this study is to test the efficacy of radiofrequency ablation of the medial branch nerves (RFA-MBN) in relieving pain and improving physical function in patients with subacute and chronic vertebral compression fractures (VCF).

Eligibility Criteria

Inclusion

I• Inclusion

  • 18-90 years old

  • Male or female

  • Age of fracture greater than or equal to 6 weeks

  • Single Level Vertebral Compression Fracture

  • Vertebral compression fracture Thoraic-9 to Lumbar-5

  • NRS >6/10

• Exclusion

  • <18 or >90 yo

  • Uncorrectable Coagulopathy

  • Multiple Level Vertebral Compression Fractures

  • Surgery within 60 days of presentation

  • Active infection

  • Rhuematologic disease

  • Significant neurologic deficit

  • Radicular pain

  • Chronic low back pain in last year

  • Inability to give consent

  • Cognitive impairment

  • Patients with Ongoing Litigation or Worker's Compensation Cases

Study Design

Treatment Group(s): 6
Primary Treatment: Radiofrequency ablation of the medial branch nerves
Phase: 4
Study Start date:
April 10, 2019
Estimated Completion Date:
December 19, 2023

Study Description

The study examines a novel approach to treat pain associated with VCFs. The usual care therapy currently involves utilizing physical therapy, non-steroidal anti-inflammatory medications, opioids, and bone re-building medications known as bisphosphonates. A usual treatment plan may include some, if not all the above. There is growing evidence that the posterior spinal elements contribute to pain that patients with VCFs experience. RFA-MBN, which targets these posterior spinal elements, may provide more sustained pain relief and improved physical function compared to usual care for these fractures. The procedure essentially "ablates with heat" the medial branch nerves which send pain signals from the posterior elements to the brain.

Patients will be randomly selected into one of two groups. The treatment group will receive the RFA-MBN procedure along with usual care therapy. The control group will undergo usual care. The control group will have the option to cross over to receive RFA-MBN at a defined interval during the study. There will be follow up visits at various intervals to compare pain relief and function based on various surveys of the treatment, control, and cross-over groups.

Connect with a study center

  • UC Davis Medical Center

    Davis, California 95817
    United States

    Site Not Available

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