Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Obsessive Compulsive Disorder

Last updated: September 7, 2022
Sponsor: Shanghai Mental Health Center
Overall Status: Active - Recruiting

Phase

N/A

Condition

Anxiety Disorders

Obsessive-compulsive Disorder

Panic Disorders

Treatment

N/A

Clinical Study ID

NCT03649685
SMHC-OCD-003
  • Ages > 18
  • All Genders

Study Summary

This study will evaluate the possible therapeutic effects of repetitive transcranial magnetic stimulation(rTMS) in obsessive-compulsive disorder (OCD) in OCD patients who have not fully responded to pharmacotherapy, and the underlying neural mechanism by EEG.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • age>18 years old;
  • DSM-5 criteria for OCD;
  • Y-BOCS total score > or = 16, despite treatment with an adequate trial of a serotoninreuptake inhibitor (SRI) and currently using adequate, stable dose of SRI at least 4weeks. An adequate SRI trial is defined as treatment for at least 12 weeks on the SRI,that meets or exceeds the recommended dosage level for OCD;
  • >or＝9 yrs education

Exclusion

Exclusion Criteria:

  • any additional current psychiatric comorbidity, except for obsessive-compulsivepersonality disorder
  • serious suicide risk;
  • the inability to receive rTMS because of metallic implants, or history of seizures，orhistory of head injury, or history of neurosurgery;
  • any major medical disease;
  • pregnancy or nursing of an infant;
  • participation in current clinical study;
  • current use of any investigational drug;
  • TMS/DBS treatment at any point in their lifetime;
  • history of long-time use of benzodiazepines

Study Design

Total Participants: 120
Study Start date:
July 15, 2019
Estimated Completion Date:
April 30, 2023

Study Description

The purpose of study is to examine the efficacy of rTMS over different brain areas, including the bilateral supplement motor Area (SMA), the right dorsal lateral prefrontal cortex (DLPFC) and SMA+DLPFC in the treatment of OCD. 120 OCD patients will be randomized into four groups. Continuous theta burst stimulation (cTBS) stimulation will be performed once a day, five times a week, for four weeks. The investigators will assess improvement after four weeks of cTBS. Though the study, Yale-Brown Obsessive Compulsive Scale（Y-BOCS）, the Dimensional Yale-Brown Obsessive-Compulsive Scale (DY-BOCS), the Barratt Impulsiveness Scale-11 (BIS-11), the Beck Depression Inventory(BDI), the Beck Anxiety Inventory (BAI), Perceived Stress Scale(PSS), Pittsburgh sleep quality index(PSQI), the Obsessive-Compulsive Inventory-Revised(OCI-R) and side effects will be obtained by a trained investigator. The patients will also receive magnetic resonance imaging scan and electroencephalography (EEG).

Connect with a study center

  • Shanghai Mental Health Center

    Shanghai, Shanghai 200030
    China

    Active - Recruiting

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