Natural Versus Artificial Cycle for Frozen-Thawed Embryo Transfer

Last updated: February 25, 2025
Sponsor: Universitaire Ziekenhuizen KU Leuven
Overall Status: Completed

Phase

4

Condition

In Vitro Fertilization

Treatment

Micronized progesterone

Estradiol Valerate

Natural cycle

Clinical Study ID

NCT03642665
S61372
  • Ages 18-45
  • Female

Study Summary

This study evaluates clinical pregnancy rates, obstetrical outcome parameters, costs and patient preferences in natural cycle versus artificial cycle frozen embryo transfers (FET).

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Women undergoing FET after a first, second or third fresh IVF/ICSI cycle

  • Single embryo transfer (SET) or Double embryo transfer (DET)

  • Female age between 18-45 year

  • Women having a natural ovulatory cycle (24-35 days)

  • Normal uterine cavity (fundal indentation at the cavity <10mm)

  • Written informed consent

Exclusion

Exclusion Criteria:

  • Use of donor gametes

  • BMI > or equal to 35 kg / m2

  • Any contra-indication to estrogen or progesterone supplementation (e.g. history ofthrombosis, prior or current hormone-sensitive malignancy...)

Study Design

Total Participants: 554
Treatment Group(s): 3
Primary Treatment: Micronized progesterone
Phase: 4
Study Start date:
September 25, 2018
Estimated Completion Date:
November 01, 2024

Study Description

Transfer of cryopreserved embryos can be performed in a natural cycle (NC-FET) or in an artificially prepared cycle (AC-FET). Both cycle regimens have their advantages and disadvantages. So far, most comparative studies have failed to identify the optimal protocol for FET. In this study patients undergoing FET will be randomized between an endometrial preparation by a natural cycle or by an artificial cycle (by oestradiol validate and micronized progesterone).

Connect with a study center

  • UZ Leuven

    Leuven, 3000
    Belgium

    Site Not Available

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