Acute Exposure to High Altitude on Pulmonary Artery Pressure and Right Heart Function (Echo) Under Exercise

Last updated: January 6, 2020
Sponsor: University of Zurich
Overall Status: Completed

Phase

N/A

Condition

Scleroderma

Stress

Heart Disease

Treatment

N/A

Clinical Study ID

NCT03637179
2018-00455_B4
  • Ages > 18
  • All Genders

Study Summary

Randomized crossover Trial in patients with Pulmonary Hypertension (PAH, CTEPH) to assess the acute response to High Altitude (2500m above sea level) on pulmonary artery pressure and right heart function (Echo) under exercise.

Eligibility Criteria

Inclusion

Inclusion Criteria

  • Informed consent

  • PH diagnosed according to internation Guidelines: mPAP ≥ 25 mmHg along with a PAWP ≤15mmHg during right heart catheterization at the time of Initial diagnosis

  • PH class 1 (PAH) or 4 (CTEPH)

  • Stable condition, on the same medication for > 4 weeks

  • Patient live permanently at an altitude < 1000m asl.

Exclusion

Exclusion Criteria:

  • Resting PaO2 ≤7.3 kPA corresponding to the requirement of long-term oxygen therapy > 16hour daily (nocturnal oxygen therapy alone is allowed)

  • Severe daytime hypercapnia (pCO2 > 6.5 kPa)

  • Susceptibility to high altitude related diseases (AMS, HAPE, etc.) based on previousexperienced discomfort at altitudes.

  • Exposure to an altitude >1500m for ≥3 nights during the last 4 weeks before the studyparticipation

  • Residence > 1000m above sea level

  • Inability to follow the procedures of the study, e.g. due to language problems,psychological disorders, neurological or orthopedic problems with Walking disability

  • Women who are pregnant or breast feeding

Study Design

Total Participants: 28
Study Start date:
July 01, 2018
Estimated Completion Date:
January 01, 2019

Study Description

Low altitude baseline measurements will be performed in Zurich (460m asl) including Echocardiography, Right heart catheterization, six-minute walk test (6MWT), pulmonary function test, clinical assessment and blood gas Analysis.

Randomly assigned to the order of testing, the participants will be tested in Low Altitude (Zurich, 470m) and at High Altitude (2500m).

Several times within the exposure, the pulmonary artery pressure and the right heart function will be assessed by echo under exercise.

Connect with a study center

  • Respiratory Clinic, University Hospital of Zurich

    Zurich, 8091
    Switzerland

    Site Not Available

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