TACE Combined With RFA/MV Treatment in Hepatocellular Carcinoma Beyond Milan Criterial

Inclusion Criteria:

• patients diganosed with hepatocellualr carcinoma beyond Milan criteria

• the presence of a single HCC tumor ≤7 cm in diameter, or multi-nodular HCC tumors (n ≤

5. small than 7 cm in diameter;

• Child-Pugh A or B

• ECOG score 0-1;

• prothrombin time ≤16 s;

• white cell count ≥3,000/mm3, platelet count ≥40 x 109/L;Hb≥8.5 g/d;ALT/AST≤5×ULN;TB≤3mg/dl;alb≥2.8 g/dl ;Scr ≤2mg/dl

Exclusion Criteria:

• expected survival time < 12 months before random assignment;

• received anticancer surgery or procedure within one month before assignment;

• concomitant use of any other anticancer therapy(except immunotherapy and herbalmedicine ) ;

• existence of portal of hepatic vein invation or extrahepatic metastases;existence ofactive infection ;

• upper gastrointestinal hemorrhage within one month ; .other serious illness or medicalcondition.