Custodiol-N Solution Compared With Custodiol Solution in Organ Transplantation (Kidney, Liver and Pancreas)

Inclusion Criteria:

• All organs (kidney, combined kidney - pancreas and liver) Donor criteria

For All patients undergoing deceased donation:

• deceased adult (≥18 years) donors fulfilling the criteria for organ donation

For All patients undergoing living kidney donation:

• adult (≥18 years) living kidney donors fulfilling the criteria for organ donation

Patient (recipient) criteria

• recipients awaiting their transplant

• recipients ≥18 years

• recipients' signed informed consent before the transplantation Kidney / combinedkidney - pancreas recipients

• n/a Liver recipient

• full organ transplantation

Exclusion Criteria:

• All organs (kidney, combined kidney - pancreas and liver) Donor criteria (notapplicable for living kidney donors)

• • donors whose organs are all allocated out of retrieving study center

• general refusal of organ donation

• donation after cardiac death (DCD) Patient (recipient) criteria

• pregnant or lactating patients

• recipients participating in any interventional study (e.g. another study involvingcompound/interventions aimed at the reduction of preservation and / or ischemia /reperfusion injury)

• all combined allocations other than pancreas and kidney

Kidney / combined kidney -pancreas recipient

• double kidney transplantation

• pancreas retransplantation

• machine perfusion According to the KDIGO-Guidelines (2009) all patients with PRA >0%are only included in the living donation setting.

Liver recipient

• retransplantation

• machine perfusion