The Influence of a Fasting Mimicking Diet on Ulcerative Colitis

Inclusion Criteria:

• Mild to moderate Ulcerative Colitis on the partial Mayo Score out of 9 (scorebetween 2 to 7)

• Age of 18-70 at start of study (inclusive)

Exclusion Criteria:

• Women who are pregnant or nursing or expect to be pregnant

• Individuals allergic to nuts

• Individuals with a body mass index (BMI) lower than 18

• Individuals diagnosed with a serious medical condition as defined by the patient'sphysician, unless approved in writing by a physician

• Individuals who have been severely weakened by a disease or medical procedure,

• Individuals who are taking medication which may not be safely consumed with acalorie restricted diet

• Individuals with diabetes who are taking anti-diabetic drugs associated with risk ofhypoglycemia

• Individuals with more than mild-moderate cardiovascular disease or life-threateningcancer (as determined by patient's physician) unless approved by a physician

• Individuals with history of severe cardiac disease (particularly uncompensatedcongestive heart failure NYHA grade 2 or more or LVEF < 40%)

• Individuals with a history of syncope

• Individuals with dietary needs incompatible with the FMD meal plan

• Individuals with liver or kidney disorders that may be affected by very low glucoseand protein content of the diet.

• Patients on a caloric restricted diet will also be excluded.

• Patients with relevant prior gastrointestinal surgery and consequences such as shortbowel syndrome, ostomy of small or large intestine, hemi- or total colectomy,proctocolectomy, ileoanal pouch will be excluded.