Brain Mechanisms of Juvenile Fibromyalgia

Phase

N/A

Condition

Fibromyalgia

Treatment

Functional Magnetic Resonance Imaging

Clinical Study ID

NCT03612258

CIN_brainjfm_001

Ages 13-17
Female
Accepts Healthy Volunteers

Study Summary

This study evaluates whether differences exist between adolescent females with juvenile-onset fibromyalgia and healthy controls in processing of pain and emotion at the neural level as assessed by functional magnetic resonance imaging (fMRI). The study includes a longitudinal component to evaluate changes in neural processing of pain and emotion before and after different treatment strategies.

Eligibility Criteria

Inclusion

Inclusion Criteria:

Diagnosis of Juvenile Fibromyalgia (by a pediatric rheumatologist or pain physicianusing 2010 American College of Rheumatology criteria)
Right handed
Functional Disability Index score ≥ 7, indicating at least mild disability
Stable medication regimen for 3 weeks prior to MRI scan

Exclusion

Exclusion Criteria:

Non-MRI compatible metal objects in the body (including braces, permanent upperretainers)
Comorbid rheumatic disease (e.g. juvenile arthritis, systemic lupus erythematosus)
Major psychiatric diagnoses (e.g. bipolar disorder, obsessive compulsive disorder,schizophrenia) or documented developmental delay
Taking opioid pain medication

Study Design

Functional Magnetic Resonance Imaging

February 28, 2018

July 31, 2024

Study Description

Juvenile-onset fibromyalgia (JFM) is a chronic, widespread pain condition that primarily affects females. Previous work has shown increased sensitivity to painful and non-painful sensory stimuli in adults with fibromyalgia, as well as brain processing abnormalities associated with these stimuli. These abnormalities in adults are highly predictive of fibromyalgia status (as opposed to healthy status) in adults. Although JFM has some similar symptoms and features to fibromyalgia in adults, the neural mechanisms of JFM may be partially different, given the moment of sharp brain development characterising JFM. fMRI scans will be completed before and after different treatments for JFM (e.g. neuromuscular training + cognitive behavioral therapy, graded aerobic exercise) to investigate the effects of treatment on brain measures related to pain, fatigue and emotion processing.

Connect with a study center

Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio 45229
United States
Site Not Available

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