Auricular Concha Electro-acupuncture for the Treatment of Depression

Last updated: April 19, 2019
Sponsor: China Academy of Chinese Medical Sciences
Overall Status: Active - Recruiting

Phase

1

Condition

Depression

Treatment

N/A

Clinical Study ID

NCT03607331
ChinaACMS-5
  • Ages 18-65
  • All Genders

Study Summary

The objective of this study was to compare the therapeutic effects of Auricular Concha Electro-acupuncture and Citalopram on patients with major depressive disorder (MDD).

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. The diagnosis is consistent with DSM-V diagnostic criteria for mild-to- moderatedepression;

  2. Patients with the first onset or recurrence of the disease have not been treated withantidepressant or without antidepressant treatment before treatment for 3 months;

  3. Age from 18 to 65 years old, with no gender;

  4. Outpatient;

  5. 17 Item Hamilton Depression Rating Scale (HAMD-17) score > 7, and <24;

  6. Signed informed consent.

Exclusion

Exclusion Criteria:

  1. In addition to depression, it conforms to the diagnostic criteria of any psychiatricdisease;

  2. Patients with a history of schizophrenia or other mental illness;

  3. Patients with cognitive impairment or personality disorder;

  4. In the past 6 months, patients who have met the DSM-V criteria for substance relatedand addictive disorders;

  5. Before entering the group, any other antidepressant treatment is being accepted;

  6. Patients with serious body disease, such as heart disease (namely Ⅱ and Ⅱ abovecardiac function) , obvious abnormalities of liver and kidney function (Biomarkersmore than 3 times normal);

  7. Serious suicidal ideation or suicidal behavior.

Study Design

Total Participants: 106
Study Start date:
September 17, 2018
Estimated Completion Date:
August 01, 2019

Study Description

In this study, 106 patients with MDD were randomly divided into the auricular concha electro-acupuncture group and the citalopram group by the evaluation blind method and randomized control design, and were treated for 8 weeks and 4 weeks follow-up. In No. 0, 2, 4, 6, 8, 10, 12 Weekend, Hamilton Rating Scale for Depression-17 Item (HAM-D17) and Hamilton Anxiety Rating Scale (Ham-A) were performed for all patients. During the No. 0/8 weekend, patients were tested and analyzed for peripheral blood NE, 5-HT, DA, Cortisol, ACTH, GABA, glutamic acid, BDNF and BFGF, and the brain is also examined and analyzed by fMRI.

Connect with a study center

  • Institute of Acupuncture and Moxibustion

    Beijing, Beijing
    China

    Active - Recruiting

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