Evaluate F901318 (Olorofim) Treatment of Invasive Fungal Infections in Participants Lacking Treatment Options

Inclusion Criteria:

• Male and female aged at least 18 years, or male and female aged 16 years or 17 yearsand who weigh at least 40 kg whom have given informed consent

• Ability and willingness to comply with the protocol.

• Able to take oral medication

• Females must be non-lactating and at no risk of pregnancy

• Male with female partners of childbearing potential must either abstain from sexualintercourse or use a highly effective means of contraception

• Participants with invasive fungal disease

• Participants who have limited alternative treatment options

Exclusion Criteria:

• Women who are pregnant or breastfeeding.

• Known history of allergy, hypersensitivity, or any serious reaction to any componentof the study drug.

• Participants with chronic aspergillosis, aspergilloma or allergic bronchopulmonaryaspergillosis.

• Human Immunodeficiency Virus (HIV) infection but not currently receivingantiretroviral therapy.

• Participants with a medical condition that may jeopardize adherence to the protocolor may cause unacceptable additional risk to the participant

• Previously enrolled participants or participants enrolled in any clinical trialwithin the last 30 days

• Participants receiving treatment limited to supportive care due to predicted shortsurvival time.

• Prohibited concomitant medications.

• Any exclusion criteria required by local regulatory authorities.