BDD With UDCA Therapy After Laparoscopic Cholecystectomy

Last updated: July 16, 2018
Sponsor: Ewha Womans University Mokdong Hospital
Overall Status: Active - Recruiting

Phase

3

Condition

Gall Bladder Disorders

Liver Disease

Intra-abdominal Infections

Treatment

N/A

Clinical Study ID

NCT03578055
BULQ-LC trial
  • Ages > 18
  • All Genders

Study Summary

Prospective Study for the Effects of Biphenyl Dimethyl Dicarboxylate and Ursodeoxycolic Acid Therapy on Liver Function and Quality of Life After Laparoscopic Cholecystectomy

Primary endpoint: peak level of postoperative AST (aspartate transaminase) and postoperative ALT (alanine tansaminase)

Secondary endpoint: postoperative GIQLI (Gastrointestinal Quality of Life index) score

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients scheduled for surgery due to chronic cholecystitis and acute cholecystitis

Exclusion

Exclusion Criteria:

  • Failure to obtain consent

  • Under 19 years

  • If you have intellectual ability to understand this study

  • When performing cholecystectomy with other operations

  • Total bilirubin levels> 2 mg / dl

  • If you are enrolled in another clinical trial

Study Design

Total Participants: 172
Study Start date:
April 24, 2018
Estimated Completion Date:
December 31, 2019

Study Description

Because the gallbladder is adjacent to the liver, liver enzymes are often elevated when cholecystitis occurs. BDD and UDCA drugs are known to be effective in preserving liver function. The use of BDD and UDCA drugs in patients with cholecystitis is expected to inhibit elevated liver enzyme levels and to maintain liver function. The aim of this study is to analyze the effects of BDD and UDCA medication on postoperative changes in hepatic enzyme levels and quality of life in patients LFT elevated cholecystitis.

Connect with a study center

  • Ewha Womans University Mokdong Hospital

    Seoul, 07985
    Korea, Republic of

    Active - Recruiting

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