Is There an Interaction Between Recurrent Miscarriage and Dental Health

Last updated: July 17, 2018
Sponsor: Recep Tayyip Erdogan University Training and Research Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Miscarriage

Oral Medicine

Treatment

N/A

Clinical Study ID

NCT03577314
40465587-179
  • Ages 18-35
  • Female
  • Accepts Healthy Volunteers

Study Summary

Oral infections can trigger the production of pro-inflammatory mediators that may be risk factors for miscarriage. The investigators investigated whether oral health care patterns that may promote or alleviate oral inflammation were associated with the history of miscarriage in Turkish women.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • history of at least two unexplained recurrent miscarriage below 20th week of pregnancy

  • systemically healthy females with at least two normal births

  • no poor obstetric history such as preeclampsia and premature birth

Exclusion

Exclusion Criteria:

  • history of thyroid disease, hyperprolactinemia, antiphospholipid syndrome, systemiclupus erythematosus, autoimmune diseases, thrombophilia, diabetes mellitus,uterine/cervical abnormalities, polycystic ovary syndrome, active liver disease,cardiovascular disease, premature ovarian failure, acute or chronic upper respiratorytract diseases, IVF pregnancy, multiple pregnancy, preeclampsia, arterial or venousembolism, infection,

  • habit of smoking, alcohol, drug or caffeine,

  • abnormal embryo karyotype,

  • infection with hepatitis B or C, and HIV,

  • chromosomal abnormalities,

  • dental fluorosis,

  • fluoride supplements,

  • orthodontic appliances,

  • body mass index ≥ 30 kg / m2

  • age of the partner is found to be over 40

Study Design

Total Participants: 100
Study Start date:
April 15, 2018
Estimated Completion Date:
May 15, 2019

Study Description

Power analysis was performed with the G-Power software package to determine sample size.

To cover possible data loss, 10% of a group were added to each group. Medical and dental examination will be performed both of control and experimental groups. In dental examination decayed, missing, or filled teeth (DMFT) index will be used according to World Health Organization (WHO 1997) criteria. All teeth were visually using the International Caries Detection and Assessment System (ICDAS-II).

To analyze the correlation between oral health status and miscarriage linear regression test and for comparison of both the groups (case and control), two sample t test and chi square test were used.

Connect with a study center

  • Recep Tayyip Erdogan University Dentistry Faculty

    Rize, 53000
    Turkey

    Active - Recruiting

  • Recep Tayyip Erdogan University Faculty of Medicine

    Rize, 53000
    Turkey

    Site Not Available

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