Study Evaluating Efficacy and Safety of PF-04965842 in Subjects Aged 12 Years And Older With Moderate to Severe Atopic Dermatitis

Inclusion Criteria:

• 12 years of age or older with a minimum body weight of 40 kg

• Diagnosis of atopic dermatitis (AD) for at least 1 year and current status of moderateto severe disease (>= the following scores: BSA 10%, IGA 3, EASI 16, Pruritus NRSseverity 4)

• Recent history of inadequate response or inability to tolerate topical AD treatmentsor require systemic treatments for AD control

Exclusion Criteria:

• Unwilling to discontinue current AD medications prior to the study or requiretreatment with prohibited medications during the study

• Prior treatment with JAK inhibitors

• Other active nonAD inflammatory skin diseases or conditions affecting skin

• Medical history including thrombocytopenia, coagulopathy or platelet dysfunction, Qwave interval abnormalities, current or history of certain infections, cancer,lymphoproliferative disorders and other medical conditions at the discretion of theinvestigator

• Pregnant or breastfeeding women, or women of childbearing potential who are unwillingto use contraception