Effects of Minimal and High Flow Anesthesia on Thiol Disulfide Balance and StO2 in Hypotensive Anesthesia Applications

Last updated: June 19, 2018
Sponsor: Recep Tayyip Erdogan University Training and Research Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Stress

Treatment

N/A

Clinical Study ID

NCT03563833
2018/64
  • Ages 18-60
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The effects of Minimal Flow Anesthesia (0.4 l / min) and High Flow Anaesthesia (2 l / min) on tissue oxygen saturation (St02) and thiol / disulfide balance in hypotensive anesthesia operations will be investigated.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • ASA (American Society of Anesthesiologists) I tympanoplasty operations withhypotensive anesthesia,

  • ASA (American Society of Anesthesiologists) II tympanoplasty operations withhypotensive anesthesia,

Exclusion

Exclusion Criteria:

  • operations in less than one hour

  • uncontrolled hypertension

  • DM (Diabetes Mellitus)

  • cerebrovascular disease

  • coagulopathy

  • morbid obesity ((BMI ≥ 35)

  • renal disease

Study Design

Total Participants: 70
Study Start date:
May 04, 2018
Estimated Completion Date:
November 30, 2018

Study Description

The oxidative stress at the cellular level and the possible effects of general anesthesia techniques on the antioxidant system make the method of anesthesia more important.

The effects of Minimal Flow Anesthesia (0.4 l / min) and High Flow Anaesthesia (2 l / min) on tissue oxygen saturation (St02) and thiol / disulfide balance in hypotensive anesthesia operations will be investigated.

Minimal flow anesthesia is widely used because of its advantages such as cost reduction, prevention of environmental pollution, minimization of heat and humidity loss.

Hypotensive anesthesia is preferred in some specialized surgical procedures in order to reduce bleeding and improve the surgical field of view.

The use of hypotensive anesthesia and inhalation agents may cause hypoperfusion at the tissue level and cause hypoxia-induced oxidative stress and initiate cell damage.

Determining the ideal anesthesia technique in terms of oxidative stress and tissue perfusion will reduce intra- and postoperative risks by protecting patients from the harmful effects of anesthesia.

Connect with a study center

  • Recep Tayyip Erdoğan University Training and Research Hospital

    Rize, 53200
    Turkey

    Active - Recruiting

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