Effects of Intraoperative Normal Saline vs Lactated Ringer on Outcomes in Pediatric Liver Transplantation

Last updated: June 19, 2018
Sponsor: RenJi Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Gall Bladder Disorders

Treatment

N/A

Clinical Study ID

NCT03563378
2017-162
  • Ages 3-6
  • All Genders

Study Summary

Lactated Ringer(LR) has been extensively used to maintain and replace intravascular volume in a variety of anesthetic procedures. However, the utility of LR in pediatric with hepatic failure undergoing liver transplantation is unclear, because addition of exogenous lactate may increase lactate concentration. In addition,large amounts of normal saline(NS) which does not contain lactate can induce a hyperchloremic metabolic acidosis and have been asociated with adverse effects on kidney injury, coagulation, and death. Accordingly, the investigators performed a double-blinded randomized trial comparing the effects of intraoperative NS or LR on outcomes in pediatric receiving Liver transplantation.

Eligibility Criteria

Inclusion

Criteria Inclusion Criteria:

  1. Pediatric patients between the age of 3 month and 6 years

  2. Scheduled for living donor liver transplantation

Exclusion

Exclusion Criteria:

  1. Re-transplantation

  2. Combined liver and kidney transplantation

  3. Congenital heart disease

  4. Refused to participate the study

Study Design

Total Participants: 200
Study Start date:
July 28, 2018
Estimated Completion Date:
May 27, 2020

Connect with a study center

  • Renji Hospital

    Shanghai, Shanghai 200127
    China

    Active - Recruiting

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.