Vienna Vascular Liver Disease Study

Last updated: December 30, 2023
Sponsor: Medical University of Vienna
Overall Status: Active - Recruiting

Phase

N/A

Condition

Liver Disease

Vascular Diseases

Thrombosis

Treatment

N/A

Clinical Study ID

NCT03541057
VALID 1928/2017
  • Ages 18-100
  • All Genders

Study Summary

The aim of this Register Trial is to systematically study the epidemiology, risk factors, liver function as well prognosis of patients with vascular liver diseases. Furthermore, important clinical parameters will be assessed in order to evaluate patients' coagulation status and in order to develop new biomarkers derived from blood, urine, stool or ascites of patients as well as histological samples from the upper / lower GI-tract or the liver in order to better understand the natural history of vascular liver diseases.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Diagnosis of a vascular liver disease by imaging (sonography, CT, MRI), transientelastography or liver histology
  • PVT: Portal vein thrombosis
  • NCPH: non-cirrhotic Portal Hypertension
  • PSVD: porto-sinusoidal vascular disorder
  • BCS: Budd-Chiari-Syndrome
  • SOS: sinusoidal occlusive disease
  • HHT: hereditary hemorrhagic teleangiectasia
  • CIRCAD: cirrhosis cardiaque
  • Age >18 years and <100 years
  • Written informed consent obtained

Exclusion

Exclusion Criteria:

  • withdrawal of written informed consent

Study Design

Total Participants: 200
Study Start date:
December 12, 2017
Estimated Completion Date:
December 31, 2024

Study Description

We will include patients with vascular liver diseases, including

  • portal vein thrombosis (PVT)

  • Budd-Chiari Syndrome (BCS)

  • Heredetary Hemorrhagic Teleangiectasia (HHT, or Osler-Rendu Disease)

  • Noncirrhotic-portal hypertension (NCPH) and Porto-sinusoidal vascular disorder

  • Cirrhosis cardiaque if the fulfill inclusion/exclusion criteria and provide written informed consent. Participation in the biobank is optional for the patients. In particular, we will study the natural course of the patients in regard to hepatic decompensation (ascites, variceal bleeding, hepatic encephalopathy), need for intensified treatment (TIPS, ICU, liver transplantation) and survival.

Connect with a study center

  • Medical University of Vienna

    Vienna, 1090
    Austria

    Active - Recruiting

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