Automated Oxygen Administration in Patients With Hypoxemic Pneumonia and Pleuropneumonia

Last updated: August 1, 2024
Sponsor: University Hospital, Toulouse
Overall Status: Active - Recruiting

Phase

N/A

Condition

Pneumonia

Treatment

O2 standard

O2 automated

Clinical Study ID

NCT03527992
RC31/17/0404
2017-A03642-51
  • Ages > 18
  • All Genders

Study Summary

Hypoxemic pneumonia is a major cause of hospitalization in Pulmonology. The patient's dependency on oxygen prevents early discharge from the hospital. An automated oxygen therapy is a system that allows administration of oxygen with a flow that is automatically adjusted to the patient's saturation, which is continuously monitored. This system has proven to be particularly effective with chronic obstructive pulmonary disease (COPD) patients, by decreasing the time spent in hypoxia and hyperoxia, and by accelerating the weaning of oxygen. Our hypothesis is that automated oxygen therapy leads to a diminution on the length of hospital stay.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Adult

  • Patient living at home or in an institution

  • Patient hospitalized for less than 48 hours

  • Pneumonia defined (according to the 2006 French-speaking infectious pneumologysociety (SPILF) criteria) by:

  • respiratory functional symptoms (cough, sputum, dyspnea, chest pain) and

  • Hyperthermia >38,5°C or hypothermia <36°C and

  • Radiological Signs of Pneumonia

  • Hypoxia : SpO2 < 94% in ambient air and/or PaO2< 60 mmHg in ambient air

Exclusion

Exclusion Criteria:

  • Pneumonia acquired at the hospital.

  • Patient hospitalized in another department more than 48 hours before admission

  • Chronic respiratory failure

  • Active neoplasia

  • Patients undergoing oxygen therapy and / or long-term NIV

  • Associated cardiac decompensation (clinical signs and / or NTproBNP> 1800ng / mL) (3

  • Initial Need for high flow oxygen therapy or ventilatory support (NIV, VI)

  • Difficulties expected from home support.

Study Design

Total Participants: 128
Treatment Group(s): 2
Primary Treatment: O2 standard
Phase:
Study Start date:
March 09, 2018
Estimated Completion Date:
October 31, 2028

Study Description

Prolonged hospitalization has many consequences, including loss of autonomy and nosocomial infection. Moreover, these complications themselves lead to an extension of the length of stay. This has an impact on the cost of care: several studies have shown that hospitalization is the most costly factor in the management of pneumonia, and that even a small amount of hospital stay, led to significant financial savings. Automated oxygen therapy is a device that automatically adjusts with the saturation the amount of oxygen administered. Investigator hypothesis is that automated oxygen therapy could shorten the length of stay of patients hospitalized for hypoxemic pneumonia. One group of patients will receive the automated oxygen therapy and the other group will receive the standard Oxygen therapy. The investigator will compare in each group the average length of stay, the duration of oxygen therapy, the time spent outside of the target saturation, the cost on the medical-economic level and the patient's experience.

Connect with a study center

  • CHU Larrey

    Toulouse, 31049
    France

    Active - Recruiting

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