Effect of Dexmedetomidine on Stress Study of Pituitrin in Laparoscopic Hysteromyoma Surgery

Phase

Condition

Uterine Fibroids

Uterina Myoma

Sarcoma (Pediatric)

Treatment

N/A

Clinical Study ID

NCT03524950

D to stress study of pituitrin

Ages 40-60
Female
Accepts Healthy Volunteers

Study Summary

This study is about the effect of dexmedetomidine to the stress of pituitrin in laparoscopic hysteromyoma surgery. It is well known that pituitrin has been widespread used in the laparoscopic hysteromyoma surgery. Pituitrin includes oxytocin and vasopressin. Vasopressin increase body stress reaction through hypothalamic pituitary adrenal(HPA) axis. The HPA axis has has main role to the body stress reaction. Dexmedetomidine can inhibit the stress responses mediated by the sympathetic nervous system. Therefore,the effect of dexmedetomidine to the stress of pituitrin in laparoscopic hysteromyoma surgery is worth to be studied.

Eligibility Criteria

Inclusion

Inclusion Criteria: Surgery will be scheduled as first case in the morning at 9 Am. On arrival to the operationroom, intravenous access will be achieved with venous cannula under local anesthesia with 2% lidocaine. Monitoring consisted of 5 lead electrocardiography, pulse oximeter,noninvasive blood pressure, end tidal carbon dioxide, and bispectral index.

Exclusion

Exclusion Criteria: Diabetic,chronic hypertension,patients on drugs such as beta blockers or calcium channelblockers,pregnant or lactating women, patients with abnormal serum creatinine and bloodurea nitrogen, and patients with a history of allergy to drugs particularly α2 agonists.

Study Design

June 01, 2018

December 31, 2019