Maintenance Treatment With BGB-290 Versus Placebo in Participants With Platinum-sensitive Recurrent Ovarian Cancer

Last updated: March 13, 2026
Sponsor: BeiGene
Overall Status: Active - Not Recruiting

Phase

3

Condition

Ovarian Cancer

Vaginal Cancer

Pelvic Cancer

Treatment

Pamiparib capsule

Placebo capsule

Clinical Study ID

NCT03519230
BGB-290-302
ChiCTR1800014643
CTR20171666
  • Ages > 18
  • Female

Study Summary

To evaluate the efficacy, safety and tolerability of maintenance therapy with BGB-290(Pamiparib) versus placebo in Chinese participants with recurrent ovarian cancer who achieved a complete response (CR) or partial response (PR) after platinum-based chemotherapy

Eligibility Criteria

Inclusion

Key Inclusion Criteria:

  1. Histologically diagnosed high-grade serous or endometrioid ovarian cancer (includingprimary peritoneal and fallopian tube cancer)

  2. Completion of ≥2 previous platinum-containing regimens (eg, carboplatin orcisplatin)

  3. Complete response (CR) or partial response (PR) achieved with last platinum-basedchemotherapy regimen as determined by investigator per Response Evaluation Criteriain Solid Tumors (RECIST) Version 1.1

  4. Ability to be randomized ≤8 weeks after last dose of platinum

Exclusion

Key Exclusion Criteria:

  1. Prior treatment with a poly (ADP-ribose) polymerase (PARP) inhibitor

  2. Progressive disease (PD) as per CA-125 criteria before randomization

  3. Diagnosis of myelodysplastic syndrome (MDS)

  4. Known history of intolerance to the excipients of the Pamiparib capsule

NOTE: Other protocol defined Inclusion/Exclusion criteria may apply.

Study Design

Total Participants: 224
Treatment Group(s): 2
Primary Treatment: Pamiparib capsule
Phase: 3
Study Start date:
May 14, 2018
Estimated Completion Date:
January 30, 2027

Connect with a study center

  • Anhui Provincial Cancer Hospital

    Hefei, Anhui 230001
    China

    Site Not Available

  • Anhui Provincial Cancer Hospital Aka West Branch of Anhui Province Hospital

    Hefei, Anhui 230088
    China

    Site Not Available

  • Anhui Provincial Cancer Hospital Aka West Branch of Anhui Province Hospital

    Hefei 1808722, Anhui 1818058 230088
    China

    Site Not Available

  • Beijing Cancer Hospital

    Beijing, Beijing Municipality 100142
    China

    Site Not Available

  • Peking Union Medical College Hospital

    Beijing, Beijing Municipality 100730
    China

    Site Not Available

  • Peking University First Hospital

    Beijing, Beijing Municipality 100034
    China

    Site Not Available

  • Beijing Cancer Hospital

    Beijing 1816670, Beijing Municipality 2038349 100142
    China

    Site Not Available

  • Peking Union Medical College Hospital

    Beijing 1816670, Beijing Municipality 2038349 100730
    China

    Site Not Available

  • Peking University First Hospital

    Beijing 1816670, Beijing Municipality 2038349 100034
    China

    Site Not Available

  • The First Bethune Hospital of Jilin University

    Jilin, Changchun 130021
    China

    Site Not Available

  • Chongqing University Cancer Hospital

    Chongqing, Chongqing 400030
    China

    Site Not Available

  • The First Hospital Affiliated to AMU(Southwest Hospital)

    Chongqing, Chongqing 400038
    China

    Site Not Available

  • Chongqing Cancer Hospital

    Chongqing, Chongqing Municipality 400030
    China

    Site Not Available

  • Southwest Hospital

    Chongqing, Chongqing Municipality 400038
    China

    Site Not Available

  • Chongqing Cancer Hospital

    Chongqing 1814906, Chongqing Municipality 1814905 400030
    China

    Site Not Available

  • Southwest Hospital

    Chongqing 1814906, Chongqing Municipality 1814905 400038
    China

    Site Not Available

  • Sun Yat Sen Memorial Hospital, Sun Yat Sen University (North)

    Guangzhou, Guangdong 510000
    China

    Site Not Available

  • Sun Yat-Sen Memorial Hospital Sun Yat-Sen University

    Guangzhou, Guangdong 510120
    China

    Site Not Available

  • The First Affiliated Hospital of Guangzhou Medical University

    Guangzhou, Guangdong 510120
    China

    Site Not Available

  • Cancer Hospital of Shantou University Medical College

    Shantou, Guangdong 515031
    China

    Site Not Available

  • Sun Yat Sen Memorial Hospital, Sun Yat Sen University (North)

    Guangzhou 1809858, Guangdong 1809935 510000
    China

    Site Not Available

  • The First Affiliated Hospital of Guangzhou Medical University

    Guangzhou 1809858, Guangdong 1809935 510120
    China

    Site Not Available

  • Cancer Hospital of Shantou University Medical College

    Shantou 1795940, Guangdong 1809935 515031
    China

    Site Not Available

  • Guangxi Medical University Affiliated Tumor Hospital& Oncology Medical College

    Nanning, Guangxi 530021
    China

    Site Not Available

  • The Tumor Hospital Affiliated to Guangxi Medical University

    Nanning, Guangxi 530021
    China

    Site Not Available

  • The Tumor Hospital Affiliated to Guangxi Medical University

    Nanning 1799869, Guangxi 1809867 530021
    China

    Site Not Available

  • The First Affiliate Hospital of Guangzhou Medical University

    Guangzhou, Guangzhou 510120
    China

    Site Not Available

  • Harbin Medical University Cancer Hospital

    Harbin, Heilongjiang 150000
    China

    Site Not Available

  • Harbin Medical University Cancer Hospital

    Harbin 2037013, Heilongjiang 2036965 150000
    China

    Site Not Available

  • Henan Cancer Hospital

    Zhengzhou, Henan 450000
    China

    Site Not Available

  • Henan Cancer Hospital

    Zhengzhou 1784658, Henan 1808520 450000
    China

    Site Not Available

  • Hubei Cancer Hospital

    Wuhan, Hubei 430079
    China

    Site Not Available

  • Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology

    Wuhan, Hubei 430030
    China

    Site Not Available

  • Tongji Hospital of Tongji Medical College,Huazhong University of Science and Technology

    Wuhan, Hubei 430000
    China

    Site Not Available

  • Union Hospital Tongji Medical College Huazhong University of Science and Technology

    Wuhan, Hubei 430030
    China

    Site Not Available

  • Union Hospital of Tongji Medical College, Huazhong University of Science and Technology

    Wuhan, Hubei 430022
    China

    Site Not Available

  • Hubei Cancer Hospital

    Wuhan 1791247, Hubei 1806949 430079
    China

    Site Not Available

  • Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology

    Wuhan 1791247, Hubei 1806949 430030
    China

    Site Not Available

  • Union Hospital of Tongji Medical College, Huazhong University of Science and Technology

    Wuhan 1791247, Hubei 1806949 430022
    China

    Site Not Available

  • Hunan Cancer Hospital

    Changsha, Hunan 410013
    China

    Site Not Available

  • Hunan Cancer Hospital

    Changsha 1815577, Hunan 1806691 410013
    China

    Site Not Available

  • Jiangxi Maternal and Child Health Hospital

    Nanchang, Jiangxi 330006
    China

    Site Not Available

  • Jiangxi Maternal and Child Health Hospital

    Nanchang 1800163, Jiangxi 1806222 330006
    China

    Site Not Available

  • Jilin Cancer Hospital

    Changchun, Jilin 130021
    China

    Site Not Available

  • The First Hospital of Jilin University

    Changchun, Jilin 130021
    China

    Site Not Available

  • Jilin Cancer Hospital

    Changchun 2038180, Jilin 2036500 130021
    China

    Site Not Available

  • The First Hospital of Jilin University

    Changchun 2038180, Jilin 2036500 130021
    China

    Site Not Available

  • The Second Hospital of Dalian Medical University

    Dalian, Liaoning 116023
    China

    Site Not Available

  • Liaoning Cancer Hospital and Institute

    Shenyang, Liaoning 110042
    China

    Site Not Available

  • Liaoning Cancer Hospital&Institute

    Shenyang, Liaoning 110042
    China

    Site Not Available

  • The Second Hospital of Dalian Medical University

    Dalian 1814087, Liaoning 2036115 116023
    China

    Site Not Available

  • Liaoning Cancer Hospital and Institute

    Shenyang 2034937, Liaoning 2036115 110042
    China

    Site Not Available

  • Qilu Hospital of Shandong University

    Jinan, Shandong 250000
    China

    Site Not Available

  • Yantai Yuhuangding Hospital

    Yantai, Shandong 264000
    China

    Site Not Available

  • Qilu Hospital of Shandong University

    Jinan 1805753, Shandong 1796328 250000
    China

    Site Not Available

  • Yantai Yuhuangding Hospital

    Yantai 1787093, Shandong 1796328 264000
    China

    Site Not Available

  • Obstetrics and Gynecology Hospital of Fudan University

    Shanghai, Shanghai Municipality 200011
    China

    Site Not Available

  • Obstetrics and Gynecology Hospital of Fudan University

    Shanghai 1796236, Shanghai Municipality 1796231 200011
    China

    Site Not Available

  • West China Hospital Sichuan University

    Chengdu, Sichuan 610041
    China

    Site Not Available

  • West China Second University Hospital

    Chengdu, Sichuan 610101
    China

    Site Not Available

  • West China Second University Hospital

    Chengdu 1815286, Sichuan 1794299 610101
    China

    Site Not Available

  • Tianjin Medical University Cancer institute & Hospital

    Tianjin, Tianjin 300070
    China

    Site Not Available

  • Tianjin Central Hospital of Gynecology Obstetrics

    Tianjin, Tianjin Municipality 300052
    China

    Site Not Available

  • Tianjin Medical University Cancer Institute and Hospital

    Tianjin, Tianjin Municipality 300060
    China

    Site Not Available

  • Tianjin Central Hospital of Gynecology Obstetrics

    Tianjin 1792947, Tianjin Municipality 1792943 300052
    China

    Site Not Available

  • Tianjin Medical University Cancer Institute and Hospital

    Tianjin 1792947, Tianjin Municipality 1792943 300060
    China

    Site Not Available

  • Zhejiang Cancer Hospital

    Hangzhou, Zhejiang 310022
    China

    Site Not Available

  • Zhejiang Cancer Hospital

    Hangzhou 1808926, Zhejiang 1784764 310022
    China

    Site Not Available

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