Study on Prevention and Treatment of Dry Eye in Patients Using Glaucoma Drops

Inclusion Criteria:

• 18-80 years of age, diagnosed with glaucoma, including primary open-angle glaucoma orprimary angle closure glaucoma, require treatment with anti-glaucoma eye drops.

• A group: Patients using glaucoma eye drops longer than 6 months, and in accordancewith the diagnostic criteria of dry eye:

1. Subjective symptoms (required): dryness, foreign body sensation, fatigue anddiscomfort;

2. The instability of tear film (required): tear break up time (TBUT);

3. Lacrimal secretion: Schirmer I test;

4. The ocular surface damage (strengthen diagnosis): fluorescein staining (FL); inthe mentioned in ①+②（TBUT≤5s) or ①+②（TBUT≤10s)+③（<10mm）/④（FL+）。

• The choice of study eyes: Choose the eye of the patient with low basical intraocularpressure, and if the basal intraocular pressure is the same, choose the right eye forthe study.

• Voluntary participation in this clinical study, and signed informed consent.

Exclusion Criteria:

• With metabolic diseases, autoimmune diseases, connective tissue diseases, such asdiabetes, rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus,Sjogren's syndrome eat;

• Combined with cerebrovascular, liver, kidney, hematopoietic serious system desease,atumor diseases and psychosis.

• Using any artificial tears and except any clinical trials of dry eyes within twoweeks.

• With drug therapy, embolization and surgical treatment of dry eyes.

• With other eye diseases, such as eyelid defects, hypophasis, pterygium, chronicdacryocystitis, trichiasis, corneal lesions.