A Study to Examine the Safety and Efficacy of a New Drug in Patients With Symptoms of Overactive Bladder (OAB)

Inclusion Criteria:

1. Has a history of OAB for at least 3 months prior to the Screening Visit.
2. Meets either the OAB Wet or OAB Dry criteria.

Exclusion Criteria: Urology Medical History

1. Patient had an average total daily urine volume > 3000 mL in the past 6 months orduring the 14-day Run-in Period.
2. Has lower urinary tract pathology that could, in the opinion of the Investigator, beresponsible for urgency, frequency, or incontinence.
3. Has a history of surgery to correct stress urinary incontinence, pelvic organprolapse, or procedural treatments for BPH within 6 months of Screening.
4. Has current history or evidence of Stage 2 or greater pelvic organ prolapse (prolapseextends beyond the hymenal ring).
5. Patient is currently using a pessary for the treatment of pelvic organ prolapse.
6. Has a known history of elevated post-void residual volume defined as greater than 150mL.
7. Has undergone bladder training or electrostimulation within 28 days prior to Screeningor plans to initiate either during the study.
8. Has an active or recurrent (> 3 episodes per year) urinary tract infection by clinicalsymptoms or pre-defined laboratory criteria.
9. Has a requirement for an indwelling catheter or intermittent catheterization.
10. Has received an intradetrusor injection of botulinum toxin within 9 months prior toScreening.
11. Has uncontrolled hyperglycemia (defined as fasting blood glucose > 150 mg/dL or 8.33mmol/L and/or non-fasting blood glucose > 200 mg/dL or 11.1 mmol/L) or, if in theopinion of the Investigator, is uncontrolled.
12. Has evidence of diabetes insipidus.
13. Is pregnant, breast-feeding, or is planning to conceive within the projected durationof the study.
14. Has a concurrent malignancy or history of any malignancy within 5 years prior tosigning informed consent, except for adequately treated basal cell or squamous cellskin cancer or in situ cervical cancer.
15. Has uncontrolled hypertension (systolic blood pressure of ≥ 180 mmHg and/or diastolicblood pressure of ≥ 100 mmHg) or has a resting heart rate (by pulse) > 100 beats perminute.
16. Has narrow angle glaucoma (primary open angle glaucoma is not excluded).
17. Has a history of cerebral vascular accident, transient ischemic attack, unstableangina, myocardial infarction, coronary artery interventions (e.g., coronary arterybypass grafting or percutaneous coronary interventions [e.g., angioplasty, stentinsertion]), or neurovascular interventions (e.g., carotid artery stenting) within 6months prior to the Screening Visit. Has a known history of liver disease.
18. Has a history of injury, surgery, or neurodegenerative diseases (e.g., multiplesclerosis, Parkinson's) that could affect the lower urinary tract or its nerve supply.
19. Has hematuria, including microscopic hematuria according to pre-defined criteria.
20. Has clinically significant electrocardiogram (ECG) abnormality.
21. Has alanine aminotransferase or aspartate aminotransferase > 2.0 times the upper limitof normal (ULN), or bilirubin (total bilirubin) > 1.5 x ULN (or > 2.0 x ULN ifsecondary to Gilbert syndrome or pattern consistent with Gilbert syndrome).
22. Has an estimated glomerular filtration rate (eGFR) < 30 mL/min/1.73 m2.
23. Has an allergy, intolerance, or a history of a significant clinical or laboratoryadverse experience associated with any of the active or inactive components of thevibegron formulation or tolterodine formulation.
24. Is currently participating or has participated in a study with an investigationalcompound or device within 28 days prior to signing informed consent, or hasparticipated in any previous study with vibegron.