Bariatric Surgery and Pharmacokinetics of Ibuprofen

Last updated: June 5, 2025
Sponsor: Norwegian University of Science and Technology
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

Ibuprofen

Clinical Study ID

NCT03476577
2016/1145o
  • Ages 18-70
  • All Genders

Study Summary

Changes to gastric pH, gastric emptying time, gastrointestinal transit-time or the pre-systemic metabolizing effect of enzymes secreted in the mucosa may all alter the pharmacokinetics of medicines. These factors are potentially influenced by bariatric surgery. Little is so far known about how gastric bypass and sleeve gastrectomy impacts the biological availability of medication. In this study the pharmacokinetic effects of bariatric surgery on ibuprofen are investigated.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Preparing to undergo gastric bypass or sleeve gastrectomy in Central Norway

  • Being a Norwegian citizen

Exclusion

Exclusion Criteria:

  • Having previously undergone resections in the GI-tract

Study Design

Total Participants: 12
Treatment Group(s): 1
Primary Treatment: Ibuprofen
Phase:
Study Start date:
November 02, 2016
Estimated Completion Date:
October 31, 2026

Connect with a study center

  • St. Olavs University Hospital

    Trondheim,
    Norway

    Active - Recruiting

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