Diuretic Effect Evaluation of Petroselinum Crispum (Parsley) in Hypertensive Patients

Phase

N/A

Condition

Enuresis

Stress

Vascular Diseases

Treatment

N/A

Clinical Study ID

NCT03468361

IAU-DEEP

Ages 18-45
All Genders

Study Summary

The use of alternative therapy, particularly herbal treatment is becoming prevalent among patients. Many herbs are in-use for various ailments such as diabetes, digestive problems, fever, hepatitis and hypertension etc. The common belief is, herbs are safe and easy to access as compared to conventional therapy, however, most of the studies reported different side effects which may be toxic at times. These adverse effects are mostly due to incorrect use or lack of patient education.

Parsley is a plant with antioxidant, diuretic and antimicrobial properties. Literature reported use of parsley as a diuretic by different communities in throughout the world. In vitro studies in animal have also reported the diuretic effect as well as proposed mechanisms for the use of parsley as diuretic however none of the studies have been conducted to investigate the diuretic effect of parsley in humans. This study aims to evaluate the diuretic and hence antihypertensive effect of parsley in hypertensive patients.

Eligibility Criteria

Inclusion

Inclusion Criteria:

Any male or female patients with hypertension and already using conventionalmedications i.e. antihypertensive drugs. The consent forms will be provided to thepatients and only those patients which are willing to participate will be included inthe study. Patients with more than 3 co-morbidities and at high-risk conditions willnot be included in the study.

Exclusion

Exclusion Criteria:

Geriatric, pregnant and lactating patients will not be included in the study. Moreimportant, patients on diuretic medications as well as diabetes, will also be excludedfrom the study.

Study Design

March 01, 2018

January 31, 2020

Study Description

Parsley botanically known as Petroselinum crispum, belongs to the family Umbeliferae, originated from Mediterranean region however, it is cultivated almost throughout the world now-a-days. The plant has reported folkloric uses in different parts of the world; in Iran the seeds of the plant is used for different pharmacological effects including antimicrobial, kidney stones, digestive disorders etc., in Turkey the leaves of this plant is used to treat hypertension, diabetes and as a diuretic in Morocco the leaves are used for arterial hypertension, diabetes, high blood pressure and cardiac diseases in Spain the leaves of this plant are used to treat hypertension, diabetes, prostititis and anemia whereas in Serbia the leaves of the plant are used to treat urinary tract diseases and infections. Though the aforementioned literature supports the diuretic and anti-hypertensive potential of parsley however no in-vivo studies have been reported to establish its diuretic activity in human subjects. Some studies have reported diuretic activity for seed aqueous extract in rats. Still, to evaluate the effect in human subjects, an in-vivo phase-I clinical study is needed to support the pre-clinical in-vivo and in-vitro diuretic effects of this plant. Our study aims to investigate the diuretic and anti-hypertensive activity of parsley in hypertensive individuals currently using conventional medication.

Connect with a study center

FAMCO
Khobar, Eastern 31441
Saudi Arabia
Site Not Available
College of Clinical Pharmacy
Dammam, Eastern Province 31441
Saudi Arabia
Site Not Available

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