Injections of Botulinic Toxin in Plantar Lesions of Localized Epidermolysis Bullosa Simplex

Inclusion Criteria:

• Diagnosis of LEBS based on clinical symptoms and in some cases histological ormolecular findings
• Palmar skin lesions: blisters and/or : erosions, edematous and erythematous lesions,crusts. 3 lesions per foot, as a minimum
• Similar clinical severity of skin lesions on both feet
• Patient with social security
• Written consent of the patient
• Patient able to understand the study's questionnaires

Exclusion Criteria:

• Patients with only one leg and a different number of toes on each foot.
• Known hypersensitivity to botulinic toxin or its excipients
• Current treatment with aminosides
• Myasthenia
• Swallowing difficulties
• Respiratory disorders
• Past medical history of dysphagia or pneumopathy of inhalation
• Known allergy or contraindications to lidocaine, prilocaine, paracetamol or nitrousoxide
• Pregnancy (positive pregnancy test (β-HCG) for women of childbearing age, performedwithin the 2 days prior to the study. Breastfeeding.
• Contraception during 6 months from inclusion
• Mental or physical or judicial incapacity to fill the questionnaires
• Guardianship patients
• Skin infection on the soles at the time of the inclusion
• Skin lesions located on the soles, not related to LEBS (ie. post traumatic wound,wart)
• Patient suffering from dishydrosis
• Botulinic toxin injections in the previous 6 months
• Inclusion in another study in the previous 2 months