Phase III Study to Evaluate Safety and Efficacy of Ilaprazole in Patients With NERD

Inclusion Criteria:

1. Male or female aged ≥ 19 years and ≤ 80 years
2. Diagnosed with non-erosive reflux disease meeting all of the following criteria: 2-1) At least either heartburn or acid regurgitation has persisted for at least past 3months before screening 2-2) Have experienced at least either heartburn or acidregurgitation of moderate or higher intensity on at least 2 days of 7 days prior toinitiation of the investigational product 2-3) Esophageal mucosal breaks by LAClassification are not observed on upper gastrointestinal endoscopy at screening
3. Voluntarily provide written informed consent to participate in this study

Exclusion Criteria:

1. Esophageal stenosis, ulcerative stenosis, esophagogastric varices or Barrett esophagusconfirmed by past upper gastrointestinal endoscopy within 1 year prior to screening
2. Active peptic ulcer or gastrointestinal bleeding confirmed by past uppergastrointestinal endoscopy at screening or within 4 weeks prior to screening
3. Abnormal value on laboratory test at screening: 3-1) Total Bilirubin, Creatinine > Upper limit of normal (ULN) x 1.5 3-2) AlkalinePhosphatase, BUN > ULN x 2
4. Clinically significant abnormal findings on ECG (major arrhythmia, multifocal PVC,second-degree or higher AV block, etc.) within 3 months prior to screening
5. Have taken H2 receptor antagonists (H2RA), prostaglandin preparations, mucosalprotective drugs, prokinetics, etc. within 2 weeks prior to initiation of theinvestigational product administration, or has taken PPIs within 4 weeks prior toinitiation of the investigational product administration
6. Expected to continuously take nonsteroidal antiinflammatory drugs (NSAIDs) includingaspirin or steroid preparations during the study
7. Surgical or medical condition that may significantly influence the absorption,distribution, metabolism or excretion of drug, including but not limited to: historyof major gastrointestinal surgery such as gastrectomy, gastroenterostomy, colectomy,gastric bypass, gastric ligation or gastric banding; presence or history of activeinflammatory bowel disease within 12 months prior to screening; has undergone criticalsurgery that may influence gastric acid secretion with exception of surgeries such asappendectomy, cholecystectomy, and hysterectomy
8. Zollinger-Ellison syndrome; past history of alcoholism or drug abuse
9. Past history of allergic symptoms (rash, fever, pruritus, etc.) or hypersensitivity toany ingredient of the Investigational product
10. Past history of treated or untreated malignancy, with or without local recurrence ormetastasis, within 5 years prior to screening (with exception of local basal cellcarcinoma of skin)
11. Pregnant or nursing women
12. Women of childbearing potential who do not use proper contraception during the study
13. Active liver disease; ALT or AST > ULN x 2 at screening; or history of hepaticencephalopathy, esophageal varix, or portacaval shunt
14. Receiving renal dialysis or history of kidney transplantation or presence of severerenal impairment (stage 4 or 5 chronic renal disease)
15. Participated in another clinical study and took an investigational product within 3months prior to screening
16. Considered by the investigator to be ineligible to participate in this study for otherreasons