The Relationship Between Right-to-left Shunt and Brain White Matter Lesions in Patients With Migraine

Last updated: July 21, 2020
Sponsor: First Hospital of Jilin University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Migraine (Adult)

Oral Facial Pain

Metachromatic Leukodystrophy - Mld

Treatment

N/A

Clinical Study ID

NCT03418766
CAMBRAIN
  • Ages 18-50
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The purpose of the study is to evaluate the prevalence of white matter lesions in Chinese migraineurs with and without right-to-left shunt. The aim is to study the relationship among right-to-left shunt, migraine and white matter lesions.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • patients who fulfilled the criteria for migraine according to the InternationalClassification of Headache Disorders III-beta were included. healthy volunteers without a history of migraine were included as controls.

Exclusion

Exclusion Criteria:

  • Subjects were excluded from the study if they had severe arterial stenosis, aninsufficient temporal window, inadequate cubital venous access, and/or were unable toperform the Valsalva manoeuvre (VM) because of severe heart or lung disease.

Study Design

Total Participants: 1500
Study Start date:
June 15, 2018
Estimated Completion Date:
December 30, 2020

Study Description

This is a prospective multicenter study of Chinese population. Participants (normal individuals without migraine and migraineurs) are included after standardized diagnostic procedures (TCD and migraine diagnosis). For all the participants, brain MRI and c-TCD are required. Up to 10-15 study sites nationwide will be needed to recruit the planned participant population during a 1-year period.

The information of each participants will be registered, including basic facts, the longitudinal headache history, frequency, location, quality, intensity, duration, accompanied symptoms, precipitating and exacerbating factors, with or without aura, and Headache Impact Test-6 (HIT-6) questionnaire.

Connect with a study center

  • First hospital of Jilin Uni

    Changchun, Jilin 130000
    China

    Active - Recruiting

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