Defining the Skin and Blood Biomarkers of Ichthyosis

Inclusion Criteria:

• Control and ichthyosis subjects may be of either sex and must be between 1-60 yearsof age at the time of enrollment

• Ichthyosis subjects include individuals with a diagnosis Netherton syndrome,lamellar ichthyosis, or other ichthyosis subtypes

• Ichthyosis subjects should not have administered systemic immunosuppressant therapyin the month before the study

• Ichthyosis subjects should not use topical immunosuppressants in the week before thestudy

• Ichthyosis subjects should not have applied emollients to the planned biopsy siteswithin 12 hours before biopsy, but can be applied elsewhere

• Controls may have no inflammatory disease, atopy, or obvious xerosis (urticaria,food allergy, allergic rhinitis or conjunctivitis, asthma)

• Controls for skin sampling may have no observable abnormality in the sampled skinand, to further assure the normality of the "normal" skin edges, must not haveevidence of inflammation or epidermal change in the lesion to be surgically removed

• Subjects and guardians of minors must sign the approved IRB consent form(s) prior toinitiation of the study protocol

Exclusion Criteria:

• Subjects who are unable to give informed consent or assent

• Subjects who administered anti-inflammatory systemic and topical therapy oremollients that do not comply with inclusion criteria prior to blood and biopsysampling

• Subjects whose main diagnosis is deemed unsafe by the study investigator for studyparticipation