Phase
Condition
Sarcopenia
Weight Loss
Diet And Nutrition
Treatment
Control Exercise
Active Exercise
Protein Supplement
Clinical Study ID
Ages > 75 All Genders Accepts Healthy Volunteers
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
At least 1 of 5 frailty criteria, definition by Linda Fried: 1) weight loss of > 4.5kg in the last 12 months; 2) reduced grip strength in Martin Vigorimeter test: ♂ ≤ 64 kPa, ♀ ≤ 42 kPa; 3) standardized question on exhaustion as published by Fried etal.; 4) gait speed < 1 m/s; 5) 6-minute walk test < 300 meters and/or Injurious (anyinjury) low trauma fall in the last 12 months prior to enrollment
Reduced protein intake defined as a score ≤ 0.5 at item K of the Mini NutritionalAssessment (MNA)
Community-dwelling or assisted living
Exclusion
Exclusion Criteria:
Mini-mental state examination (MMSE) < 24 (inability to follow the study proceduresand give written informed consent)
Inability to come to the trial centers
Inability to walk at least 3 meters with or without walking aid
Severe kidney impairment (Glomerular filtration rate [GFR] < 30 ml/min)
Inability to follow exercise instruction or inability to take protein powder mixedin drink or food (test at baseline screening examination)
Severe gait impairment or diseases with a risk of recurrent falling (due toconditions such as, e.g. Parkinson's disease/syndrome, Hemiplegia after stroke,symptomatic stenosis of the spinal canal, polyneuropathy, epilepsy, recurringvertigo, recurring syncope)
Major visual or hearing impairment or other serious illness that would precludeparticipation (e.g. alcohol abuse, alcoholic disease)
Inability to read/speak/write in German (necessary to follow instructions incl.STRONG exercise manual)
Living in a nursing home
Contraindication to treatment (e.g. allergy)
Contraindication to the vitamin D standard of care therapy
Study Design
Study Description
Connect with a study center
Centre on Aging and Mobility, University of Zurich and City Hospital Waid and Triemli
Zurich, ZH 8037
SwitzerlandSite Not Available
University Geriatric Medicine Felix Platter, Basel
Basel, 4012
SwitzerlandSite Not Available
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