Quadratus Lumborum Block : Local Anesthesia Versus Placebo

Last updated: March 3, 2025
Sponsor: Kyungpook National University Hospital
Overall Status: Completed

Phase

N/A

Condition

Hemorrhoids

Treatment

Quadratus lumborum block using ropivacaine

Quadratus lumborum block with normal saline

Clinical Study ID

NCT03411096
KNUHC02
  • Ages 20-75
  • All Genders

Study Summary

Opioid analgesics have many side effects. Quadratus lumborum (QL) block is one kind of regional nerve block that can reduce the side effects of opioid analgesics. The investigators hypothesize that QL block with local analgesics (ropivacaine) can significantly reduce pain intensity in comparison with placebo.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Aged 20-75 years, either sex

  • Patients scheduled to undergo elective ileostomy repair surgery under generalanesthesia.

  • Patients underwent curative surgery and ileostomy due to colorectal cancer.

  • Willingness and ability to sign an informed consent document

Exclusion

Exclusion Criteria:

  • Allergies to anesthetic or analgesic medications

  • Contraindication to the use of locoregional anesthesia

  • Chronic opioid use

  • Coagulopathy, Impaired kidney function, uncontrolled diabetes, psychiatricdisorders, severe cardiovascular impairment or chronic obstructive lung disease

  • Necessity of major resection other than colorectal, palliative surgery

  • BMI above 35kg/m2

  • American Society of Anesthesiologists (ASA) physical status above 3

Study Design

Total Participants: 57
Treatment Group(s): 2
Primary Treatment: Quadratus lumborum block using ropivacaine
Phase:
Study Start date:
April 08, 2020
Estimated Completion Date:
December 31, 2024

Study Description

Opioid analgesics have been used to control the pain. However, many postoperative complication, such as nausea, vomiting, constipation, ileus, etc are related to opioid usage. Recently, local or regional pain nerve block, such as transversus abdominis plane block, wound infiltration, have been reported in several studies. Quadratus lumborum (QL) block was first introduced in the abstract of 2007 European Society of Regional Anesthesia. The effect is longer and more than that of transversus abdominis plane block because it works close to the spinal cord nerves. The QL block can be an effective pain control method for patients who underwent ileostomy closure. The aim of this study is to compare pain intensity after ileostomy closure between QL block (ropivacaine) group and placebo group (normal saline).

Connect with a study center

  • Kyungpook National University Chilgok Hospital

    Daegu, 41404
    Korea, Republic of

    Site Not Available

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